Lasers in Medical Science

, Volume 21, Issue 3, pp 134–139 | Cite as

In vivo photoacoustic imaging of blood vessels with a pulsed laser diode

  • Roy G. M. Kolkman
  • Wiendelt Steenbergen
  • Ton G. van Leeuwen
Original Article


Photoacoustic imaging is a hybrid imaging modality that is based on the detection of acoustic waves generated by absorption of pulsed light by tissue chromophores such as hemoglobin in blood. For this technique, usually large and costly Q-switched Nd:YAG lasers are used. These lasers provide a pulse energy of at least several milliJoules. In search of alternative light sources, we investigated the use of a small and compact pulsed laser diode to image blood vessels. We proved that a pulsed laser diode can be applied for imaging blood vessels in vivo.


Imaging techniques Ultrasound Blood vessels 



This work was partly funded by the Netherlands Foundation of Fundamental Research on Matter FOM (grant 00PMT22) and the Institute for BioMedical Technology (BMTI) of the University of Twente.


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Copyright information

© Springer-Verlag London Limited 2006

Authors and Affiliations

  • Roy G. M. Kolkman
    • 1
  • Wiendelt Steenbergen
    • 1
  • Ton G. van Leeuwen
    • 1
    • 2
  1. 1.Biophysical Engineering, Institute for BioMedical Technology, Faculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands
  2. 2.Laser Center, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

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