Lasers in Medical Science

, Volume 21, Issue 2, pp 90–94 | Cite as

Low-level laser therapy in management of postmastectomy lymphedema

  • Ahmad KavianiEmail author
  • Mohsen Fateh
  • Reza Yousefi Nooraie
  • Mohammad-reza Alinagi-zadeh
  • Leila Ataie-Fashtami
Original Article


The aim of this paper was to study the effects of low-level laser therapy (LLLT) in the treatment of postmastectomy lymphedema. Eleven women with unilateral postmastectomy lymphedema were enrolled in a double-blind controlled trial. Patients were randomly assigned to laser and sham groups and received laser or placebo irradiation (Ga–As laser device with a wavelength of 890 nm and fluence of 1.5 J/cm2) over the arm and axillary areas. Changes in patients’ limb circumference, pain score, range of motion, heaviness of the affected limb, and desire to continue the treatment were measured before the treatment and at follow-up sessions (weeks 3, 9, 12, 18, and 22) and were compared to pretreatment values. Results showed that of the 11 enrolled patients, eight completed the treatment sessions. Reduction in limb circumference was detected in both groups, although it was more pronounced in the laser group up to the end of 22nd week. Desire to continue treatment at each session and baseline score in the laser group was greater than in the sham group in all sessions. Pain reduction in the laser group was more than in the sham group except for the weeks 3 and 9. No substantial differences were seen in other two parameters between the two treatment groups. In conclusion, despite our encouraging results, further studies of the effects of LLLT in management of postmastectomy lymphedema should be undertaken to determine the optimal physiological and physical parameters to obtain the most effective clinical response.


LLLT Postmastectomy lymphedema Breast cancer 



Authors wish to thank Ms M. Salami, Dr S. M. Hejri, Dr M. Ghodsi, and Dr Sh. Haghighat for their great help to perform the study. We also thank Dr. Reza S. Malek, Professor of Urology, Mayo Clinic College of Medicine, and Ms. Kimberly Rinehart for their invaluable comments on the final manuscript. Mr. Mohammadian, the head of Behsaz Institute, is acknowledged for his assistance.


  1. 1.
    Tracy GD, Reeve JS, Fitz SE, Rundle FF (1961) Observation of the swollen arm after radical mastectomy. Aust NZ J Surg 30:204–208CrossRefGoogle Scholar
  2. 2.
    Kissin MW, Querci della Rovere G, Easton D, Westbury G (1986) Risk of lymphoedema following the treatment of breast cancer. Br J Surg 73(7):580–584, (Jul)PubMedCrossRefGoogle Scholar
  3. 3.
    Hoe AL, Iven D, Royle GT, Taylor I (1992) Incidence of arm swelling following axillary clearance for breast cancer. Br J Surg 79(3):261–262, (Mar)PubMedCrossRefGoogle Scholar
  4. 4.
    Pain SJ, Purushotham AD (2000) Lymphoedema following surgery for breast cancer. Br J Surg 87(9):1128–1141, (Sep)PubMedCrossRefGoogle Scholar
  5. 5.
    Petrek JA, Heelan MC (1998) Incidence of breast carcinoma-related lymphedema. Cancer 83(12 Suppl American):2776–2781, (Dec 15)PubMedCrossRefGoogle Scholar
  6. 6.
    Kocak Z, Overgaard J (2000) Risk factors of arm lymphedema in breast cancer patients. Acta Oncol 39(3):389–392PubMedCrossRefGoogle Scholar
  7. 7.
    Logan V (1995) Incidence and prevalence of lymphoedema: a literature review. J Clin Nurs 4(4):213–219, (Jul)PubMedCrossRefGoogle Scholar
  8. 8.
    Ozaslan C, Kuru B (2004) Lymphedema after treatment of breast cancer. Am J Surg 187(1):69–72, (Jan)PubMedCrossRefGoogle Scholar
  9. 9.
    Petrek JA, Lerner R (2000) Lymphedema. In: Diseases of the breast, 2nd edn. Williams & Wilkins, Baltimore, MD, pp 1033–1040Google Scholar
  10. 10.
    Donegan W, Spratt J (2002) Surgical techniques. In: Cancer of the breast, 5th edn. Saunders, Philadelphia, PA, pp 601–638Google Scholar
  11. 11.
    Meric F, Buchholz MF, Mirza NQ, Vlastos G, Ames FC, Ross MI et al (2002) Long-term complications associated with breast-conservation surgery and radiotherapy. Ann Surg Oncol 9:543–549PubMedCrossRefGoogle Scholar
  12. 12.
    Ridner SH (2005) Quality of life and a symptom cluster associated with breast cancer treatment-related lymphedema. Support Care Cancer (Apr 6) [Epub ahead of print]Google Scholar
  13. 13.
    Harris SR, Hugi MR, Olivotto IA, Levine M, Steering Committee for Clinical Practice Guidelines for the Care and Treatment of Breast Cancer (2001) Clinical practice guidelines for the care and treatment of breast cancer: 11. Lymphedema. Can Med Assoc J 164(2):191–199, (Jan 23)Google Scholar
  14. 14.
    Kligman L, Wong RK, Johnston M, Laetsch NS (2004) The treatment of lymphedema related to breast cancer: a systematic review and evidence summary. Support Care Cancer 12(6):421–431, (Jun)PubMedCrossRefGoogle Scholar
  15. 15.
    Carati CJ, Anderson SN, Gannon BJ, Piller NB (2003) Treatment of postmastectomy lymphedema with low-level laser therapy: a double blind, placebo-controlled trial. Cancer 98(6):1114–1122, (Sep 15)PubMedCrossRefGoogle Scholar
  16. 16.
    Piller NB, Thelander A (1998) Treatment of chronic postmastectomy lymphedema with low level laser therapy: a 2.5 year follow-up. Lymphology 31(2):74–86, (Jun)PubMedGoogle Scholar
  17. 17.
    Lievens PC (1991) The effect of combined HeNe and I.R. laser treatment on the regeneration of the lymphatic system during the process of wound healing. Lasers Med Sci 6:193–199CrossRefGoogle Scholar
  18. 18.
    Lievens PC (1985) The influence of laser-irradiation on the motoricity of the lymphatical system and on the wound healing process. Int Congr Laser Med Surg 171–174Google Scholar
  19. 19.
    Norman SA, Miller LT, Erikson HB, Norman MF, McCorkle R (2001) Development and validation of a telephone questionnaire to characterize lymphedema in women treated for breast cancer. Phys Ther 81:1192–1205PubMedGoogle Scholar
  20. 20.
    Farncombe ML, Robertson ED (2002) Lymphedema. In: Principles and practice of palliative care and supportive oncology, 2nd edn. Williams & Wilkins, Baltimore, MD, pp 333–343Google Scholar
  21. 21.
    Knight KR, Khazanchi RK, Pederson WC, McCann JJ, Coe SA, O’Brien BM (1989) Coumarin and 7-hydroxycoumarin treatment of canine obstructive lymphoedema. Clin Sci 77:69–76PubMedGoogle Scholar
  22. 22.
    Pecking A, Lasry S, Boudinet A, Floiras J, Rambert P, Guerin P (1988) Postsurgical physiotherapeutic treatment: interest in secondary upper limb lymphedemas prevention. In: Partsch H (ed) Progress in lymphology—proceedings of the XIth congress in Vienna, 1987. Elsievier, Amsterdam, pp 561–564Google Scholar
  23. 23.
    Szuba A, Achalu R, Rockson SG (2002) Decongestive lymphatic therapy for patients with breast carcinoma-associated lymphedema. A randomized, prospective study of a role for adjunctive intermittent pneumatic compression. Cancer 95:2260–2267PubMedCrossRefGoogle Scholar
  24. 24.
    Brosseau L, Welch V, Wells G, Tugwell P, de Bie R, Gam A et al (2000) Low level laser therapy for osteoarthritis and rheumatoid arthritis: a metaanalysis. J Rheumatol 27(8):1961–1969, (Aug)PubMedGoogle Scholar

Copyright information

© Springer-Verlag London Limited 2006

Authors and Affiliations

  • Ahmad Kaviani
    • 1
    • 4
    Email author
  • Mohsen Fateh
    • 2
  • Reza Yousefi Nooraie
    • 2
  • Mohammad-reza Alinagi-zadeh
    • 3
  • Leila Ataie-Fashtami
    • 2
  1. 1.Tehran University of Medical Sciences and Iranian Center for Medical Laser ResearchTehranIran
  2. 2.Iranian Center for Medical Laser Research, Academic Center for Education, Culture & Research (ACECR)TehranIran
  3. 3.Research Center for Science and Technology in Medicine (RCSTM)Tehran University of Medical Sciences (TUMS)TehranIran
  4. 4.Tehran University of Medical Sciences (TUMS)Imam Medical CenterTehranIran

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