Advertisement

New Aspects in the Molecular Basis of Polymer-Associated Infections due to Staphylococci

  • C. von Eiff
  • C. Heilmann
  • G. Peters
Review

Abstract

 Coagulase-negative staphylococci, particularly Staphylococcus epidermidis, cause the majority of infections associated with both temporarily inserted and permanently implanted foreign bodies. In recent years, the pathogenesis of polymer-associated staphylococcal infection has become better understood, due in part to the characterization of further associated factors. The bacterial factors involved in the two phases of biofilm formation, i.e. the rapid adherence of bacteria to the polymer surface and the subsequent, more prolonged, accumulation phase, are presented in this review. The biofilm present on infected devices plays an important role in the pathogenicity of the infecting organism by protecting the embedded staphylococci and reducing the efficacy of host defenses and antimicrobial killing.

Keywords

Polymer Foreign Body Molecular Basis Host Defense Polymer Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • C. von Eiff
    • 1
  • C. Heilmann
    • 1
  • G. Peters
    • 1
  1. 1.Institute of Medical Microbiology, Westfälische Wilhelms-Universität, Münster, Domagkstraße 10, 48149 Münster, Germany e-mail: eiffc@uni-muenster.deDE

Personalised recommendations