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Short-Term Treatment of Pertussis with Azithromycin in Infants and Young Children

  • A. Baće
  • T. Zrnić
  • J. Begovac
  • N. Kuzmanović
  • J. Čulig

Abstract

 A prospective, open, noncomparative study was conducted to assess the efficacy and safety of azithromycin given once daily for 3 or 5 days to eradicate Bordetella pertussis from the upper respiratory tract of infants and young children. Seventeen children received azithromycin in a dose of 10 mg/kg on day 1 followed by 5 mg/kg once daily for four consecutive days, and 20 were given 10 mg/kg once daily for 3 days. Seven days after the initiation of therapy, 33 of 35 (94.3%) patients had negative cultures for Bordetella pertussis. On day 14, cultures from all 34 evaluable patients were negative. These findings suggest that a controlled, comparative study of erythromycin versus short-term administration of azithromycin is justified.

Keywords

Erythromycin Pertussis Azithromycin Eradication Rate Pertussis Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • A. Baće
    • 1
  • T. Zrnić
    • 2
  • J. Begovac
    • 1
  • N. Kuzmanović
    • 1
  • J. Čulig
    • 2
  1. 1.University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Mirogojska 8 CRO-10000 Zagreb, Croatia
  2. 2.Pliva dd, Pharmaceuticals Division, Zagreb, Croatia

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