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Evolution of Resistance among Clinical Isolates of Acinetobacter over a 6-Year Period

  • J. Ruiz
  • M. L. Núñez
  • J. Pérez
  • E. Simarro
  • L. Martínez-Campos
  • J. Gómez

Abstract

 The aim of this report was to study the evolution of susceptibilities of 1532 clinical isolates of Acinetobacter recovered over a period of 6 years. The minimal inhibitory concentrations (MICs) of 15 antimicrobial agents were determined for all the isolates. The respective percentages of resistant strains in the years 1991 and 1996 were as follows: ciprofloxacin, 54.4% and 90.4%; tobramycin, 33% and 71.8%; amikacin, 21% and 83.7%; ampicillin plus sulbactam, 65.7% and 84.1%; ceftazidime, 57.4% and 86.8%; ticarcillin, 70% and 89.4%; trimethoprim plus sulfamethoxazole, 41.1% and 88.9%; and imipenem, 1.3% and 80%. The MIC90s of ciprofloxacin, sparfloxacin, biapenem, meropenem, imipenem, cefepime, cefpirome, and rifampicin against 250 imipenem-resistant Acinetobacter strains were >32, >32, 128, >256, 256, >256, 256, and 16 mg/l, respectively. With serious infections, it was necessary to resort to the use of colistin, the only antibiotic active in vitro.

Keywords

Amikacin Tobramycin Imipenem Meropenem Colistin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • J. Ruiz
    • 1
  • M. L. Núñez
    • 1
  • J. Pérez
    • 1
  • E. Simarro
    • 1
  • L. Martínez-Campos
    • 1
  • J. Gómez
    • 2
  1. 1.Laboratory of Microbiology, Hospital Universitario Virgen de la Arrixaca, Carretera El Palmar-Cartagena E-30120, Murcia, SpainES
  2. 2.Infectious Diseases Department, Hospital Universitario Virgen de la Arrixaca, Carretera El Palmar-Cartagena E-30120, Murcia, SpainES

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