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Evaluation of respiratory syncytial virus IgG antibody dynamics in mother-infant pairs cohort

Abstract

RSV is one of the most important agents of lower respiratory infections in childhood. In this study, anti-RSV antibody levels in mother-infant pairs and factors related to antibody transfer ratio were investigated. One hundred and twenty-seven women that had term babies and their babies and 84 mother-infant pairs of them who continued the study after 6 months were enrolled. Anti-RSV IgG antibodies of the mothers and infants were positive in 46.5% and 61.5%, respectively. At the sixth month, anti-RSV antibodies were negative in all infants. Median of the anti-RSV antibody levels of the mothers and infants at birth were 12.08 IU/ml (1.21–119.27) and 13.78 IU/ml (3.99–108.6), respectively. There was a significant correlation between anti-RSV antibody levels of mothers and infants at birth (p: 0.0001, r: 0.667) and anti-RSV antibody levels of infants at birth and at 6th month (p: 0.0001, r: 0.343). Median ratio of infant and mother antibody levels was 1.22 (0.14–6.05). Median ratio that was detected in appropriate for gestational age infants was significantly higher than in small for gestational age or large for gestational age infants. In this study, the significant positive correlation between maternal antibody levels and infants’ antibody levels at birth suggests that maternal vaccination strategies may be logical. We showed that antibody transfer rate was highest in appropriate for gestational age infants. It should be kept in mind that maternal vaccination strategies may be less effective in small for gestational age and large for gestational age infants.

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Abbreviations

RSV:

Respiratory syncytial virus

LRTI:

Lower respiratory tract infection

SGA:

Small for gestational age

AGA:

Appropriate for gestational age

LGA:

Large for gestational age

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Funding

This work was supported by Scientific Research Projects Coordination Unit of Istanbul University. Project number TTU-2016-23288″.

Author information

Dr. Unuvar conceptualized and designed the study. Dr. Somer, Dr. Coban, and Dr. Torun drafted the initial manuscript and reviewed and revised the manuscript. Dr. Agacfidan, Dr. Mese, and Demircili carried out the analyses. Dr. Yıldız, Dr. Kara, Dr. Sivrikoz, and Dr. Sutcu designed the data collection instruments, collected data, and reviewed and revised the manuscript.

Correspondence to Mehmet Yildiz.

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Ethical approval

This study was found to be ethically acceptable by Istanbul University Istanbul Medical Faculty Clinical Research Ethics Committee (2015/1816).

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Written informed consent was obtained from all of the participants’ parents.

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All of the authors have indicated they have no financial relationships relevant to this article to disclose.

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All of the authors have indicated they have no potential conflicts of interest to disclose.

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Yildiz, M., Kara, M., Sutcu, M. et al. Evaluation of respiratory syncytial virus IgG antibody dynamics in mother-infant pairs cohort. Eur J Clin Microbiol Infect Dis (2020). https://doi.org/10.1007/s10096-020-03841-8

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Keywords

  • Respiratory syncytial virus
  • Maternal antibodies
  • Passive immunization
  • Transplacental antibody transfer