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Clinical characteristics and treatment outcomes of Enterococcus durans bacteremia: a 20-year experience in a tertiary care hospital

  • Byung-Han Ryu
  • Jeongmin Hong
  • Jiwon Jung
  • Min Jae Kim
  • Heungsup Sung
  • Mi-Na Kim
  • Yong Pil Chong
  • Sung-Han Kim
  • Sang-Oh Lee
  • Yang Soo Kim
  • Jun Hee Woo
  • Sang-Ho ChoiEmail author
Original Article
  • 73 Downloads

Abstract

While the clinical characteristics and treatment outcomes of Enterococcus faecalis and E. faecium bacteremia are well known, those of E. durans bacteremia are still largely unclear. We retrospectively identified 80 adult E. durans bacteremia cases treated at our 2700-bed tertiary care hospital between January 1997 and December 2016. We compared the clinical characteristics and treatment outcomes of the adult patients with E. durans bacteremia (case group) with those of E. faecalis and E. faecium bacteremia cases (two control groups). The case and control groups were matched for sex, age, and date of onset of bacteremia. E. durans was responsible for 1.2% of all enterococcal bacteremia cases at our hospital. Of 80 cases, 39 (48.8%) had biliary tract infection and 18 (22.5%) had urinary tract infection. Community-onset bacteremia was more frequent in the case group than in the control groups (56.2% vs. 35.0% vs. 21.2%, p < 0.01). Infective endocarditis tended to be more common in the E. durans group (7.5% vs. 1.2% vs. 1.2%, p = 0.05). The majority of E. durans isolates were susceptible to penicillin (66/76, 86.8%), ampicillin (67/76, 88.2%), and vancomycin (75/76, 98.7%). The case group had significantly lower all-cause mortality (20.0% vs. 31.2% vs. 42.5%, p < 0.01) and bacteremia-related mortality (2.5% vs. 16.2% vs. 18.8%, p < 0.01) than the control groups. E. durans bacteremia mainly originates from the biliary or urinary tract and is associated with a lower risk of mortality.

Keywords

Enterococcus durans Enterococcus faecalis Enterococcus faecium Bacteremia Mortality 

Notes

Compliance with ethical standards

This study was approved by the Asan Medical Center Institutional Review Board.

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

10096_2019_3605_MOESM1_ESM.doc (46 kb)
ESM 1 (DOC 46 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Byung-Han Ryu
    • 1
  • Jeongmin Hong
    • 2
  • Jiwon Jung
    • 3
  • Min Jae Kim
    • 3
  • Heungsup Sung
    • 4
  • Mi-Na Kim
    • 4
  • Yong Pil Chong
    • 3
  • Sung-Han Kim
    • 3
  • Sang-Oh Lee
    • 3
  • Yang Soo Kim
    • 3
  • Jun Hee Woo
    • 3
  • Sang-Ho Choi
    • 3
    Email author
  1. 1.Department of Infectious DiseasesGyeongsang National University Changwon HospitalChangwonRepublic of Korea
  2. 2.Department of Infectious DiseasesDaegu Catholic University Medical CenterDaeguRepublic of Korea
  3. 3.Department of Infectious DiseasesAsan Medical Center, University of Ulsan College of MedicineSeoulRepublic of Korea
  4. 4.Department of Laboratory MedicineAsan Medical Center, University of Ulsan College of MedicineSeoulRepublic of Korea

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