Predicting the risk of sepsis and causative organisms following urinary stones removal using urinary versus stone and stent cultures
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The association between foreign objects in the urinary system and urinary tract infections (UTI) is well established. The incidence of bacteriuria in patient with urinary catheters increases as dwelling time lengthens. The presence of ureteral stents and kidney stones is also associated with increased risk for bacteriuria and urinary tract infection. The aim of this study was to assess the bacterial characteristics of urine culture (UC) and foreign body culture (FBC), the concordance between them, and to identify risk factors for postoperative infections, in order to improve the treatment in these patients, using a prospectively collected database of patients who underwent ureteroscopy or percutaneous nephrolithotomy (PCNL) for the treatment of urinary stones between 2005 and 2016 at our institute. Preoperative UC was obtained from voided mid-stream urine for all patients. FBCs were obtained from ureteral stents removed and stones collected during the surgery. The cohort included 1011 patients. Mean age was 53 (SD 15.8), and 679 (67.2%) patients were male. Two hundred eighteen (21.6%) had a UTI in the year prior to the surgery. Among 795 patients who had sterile UC, 98 (12.3%) patients had positive FBC. Positive FBC was found in 53.7% of the patients with positive UC; however, FBC pathogens were similar to those identified in UC in 31% patients. The sensitivity of UC to detect FBC pathogens was 31.3%, and the PPV was 0.31. Urine cultures do not recognize all cases of pathogens colonizing foreign bodies in the urinary system. The colonization may be associated with an increased risk for SIRS. In more than one-quarter of the patients, the causative pathogen of sepsis is identified by FBC, but not by UC.
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Approved by the IRB.
- 5.Jan H, Akbar I, Kamran H, Khan J (2008) Frequency of renal stone disease in patients with urinary tract infection. J Ayub Med Coll Abbottabad 20(1):60–62Google Scholar
- 16.Rosenberg M, Berger SA, Barki M, Goldberg S, Fink A, Miskin A (1992) Initial testing of a novel urine culture device. J Clin Microbiol 30(10):2686–2691Google Scholar
- 17.Cherkaoui A, Hibbs J, Emonet S et al (2010) Comparison of two matrix-assisted laser desorption ionization-time of flight mass spectrometry methods with conventional phenotypic identification for routine identification of bacteria to the species level. J Clin Microbiol 48(4):1169–1175CrossRefGoogle Scholar
- 25.Mermel LA, Allon M, Bouza E et al (2009) Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 49:1):1–1)45Google Scholar
- 26.Nevo A, Mano R, Shoshani O, Kriderman G, Schreter E, Lifshitz D (2018) Stone culture in patients undergoing percutaneous nephrolithotomy: a practical point of view. Can J Urol 25(2):9238–9244Google Scholar