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Helicobacter pylori infection in children: an overview of diagnostic methods

  • Parisa Sabbagh
  • Mostafa Javanian
  • Veerendra Koppolu
  • VeneelaKrishna Rekha Vasigala
  • Soheil EbrahimpourEmail author
Review
  • 239 Downloads

Abstract

Children differ from adults regarding Helicobacter pylori (H. pylori) infection in many terms. H. pylori infection represents a key factor in the pathogenesis of duodenal ulcer and chronic gastritis in children. H. pylori infection causes some extraintestinal diseases as well as gastrointestinal diseases. Although, among these illnesses in children, symptoms like recurrent abdominal pain are not specific. Moreover, the role of the pathogen in the growth faltering, iron deficiency anemia, and asthma still remains controversial. A reliable method to detect H. pylori infection is a crucial issue, sand is still a matter of active debate. The tests applied for H. pylori diagnosis are grouped as either invasive or non-invasive methods. Invasive methods consist of endoscopic evaluation, the rapid urease test (RUT), histology, and bacterial culture. Non-invasive tests include the urea breath test (UBT), stool antigen test (SAT), serology, and molecular diagnostic approaches. Use of endoscopy is a pre-requisite for all invasive methods and poses difficulties in children as it is a difficult procedure and requires patient’s cooperation. For this reason, the non-invasive tests have been commonly used in children, although their accuracy is not very reliable in some cases. Invasive tests may be opted to confirm the diagnosis as and when needed. This review presents the diagnostic tests used to detect H. pylori infection in children.

Keywords

Helicobacter pylori Diagnosis Children 

Notes

Acknowledgments

The authors express their appreciation to Vice Chancellor for Research and Technology of Babol University of Medical Sciences for supporting this research and Marzieh Nourollahzadeh for her advice as a translator of this article.

Specific author contributions

P.S and S.E conceived the study; M.J, V.K, V.K.R.V, and S.E collected all data; P.S and S.E drafted the manuscript; and all authors commented on the drafts of the manuscript and approved the final draft of the paper.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study received the approval from the Babol University of Medical Science, Ethical Committee.

Informed consent

There is no informed consent for this review article.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Parisa Sabbagh
    • 1
  • Mostafa Javanian
    • 1
  • Veerendra Koppolu
    • 2
  • VeneelaKrishna Rekha Vasigala
    • 3
  • Soheil Ebrahimpour
    • 1
    Email author
  1. 1.Infectious Diseases and Tropical Medicine Research Center, Health Research InstituteBabol University of Medical SciencesBabolIslamic Republic of Iran
  2. 2.Scientist Biopharmaceutical Development Medimmune GaithersburgGaithersburgUSA
  3. 3.Rangaraya Medical CollegeNTR University of Health SciencesKakinadaIndia

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