Activity of temocillin and comparators against clinical isolates of Vibrio cholerae from Iran

  • Mohammad Rahbar
  • Rogieh Saboorian
  • Sebastien Van de VeldeEmail author
  • Marjan Rahnamaye Farzami
  • Masoud Mardani
Letter to the Editor

Dear Editor,

Acute diarrhoeal caused by Vibrio cholerae is a major public health problem with, according to the World Health Organization, up to 4.0 million cholera cases and 143,000 deaths occurring every year worldwide [1]. In conjunction to aggressive rehydration therapy that restores the circulating blood volume, it is recommended to use antibiotics for the most severe patients in order to reduce the severity of the symptoms and the treatment duration [2]. Concerns are now raised due to the increase resistance of V. cholerae. The objective of this study was to investigate the in vitro activity of temocillin, a narrow-spectrum penicillin stable to many beta-lactamases [3], against V. choleraeobtained from patients suffering of cholera and submitted to the national reference health laboratory of Iran. All isolates were collected consecutively and originated from 20 different provinces in Iran (Alborz, Busheher, Esfahan, Ghazvin, Gilan, Gonabad, Gorgan, Hormozgan, Jiroft, Kashmar,...


Funding information

This investigation was funded by Belpharma S.A., Luxembourg.

Compliance with ethical standards

Conflict of interest

MR and MM have received sponsorship from Belpharma to attend scientific meetings. SVDV is an employee of Eumedica s.a. RS and MRF declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of MicrobiologyIranian Reference Health Laboratory Research Centre, Ministry of Health and Medical EducationTehranIran
  2. 2.Eumedica s.a.ManageBelgium
  3. 3.Reference Health Laboratory Research CentreMinistry of Health and Medical EducationTehranIran
  4. 4.Infectious Disease and Tropical Medicine Research CenterShahid Beheshti Medical UniversityTehranIran

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