Activity of temocillin and comparators against clinical isolates of Vibrio cholerae from Iran
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Acute diarrhoeal caused by Vibrio cholerae is a major public health problem with, according to the World Health Organization, up to 4.0 million cholera cases and 143,000 deaths occurring every year worldwide . In conjunction to aggressive rehydration therapy that restores the circulating blood volume, it is recommended to use antibiotics for the most severe patients in order to reduce the severity of the symptoms and the treatment duration . Concerns are now raised due to the increase resistance of V. cholerae. The objective of this study was to investigate the in vitro activity of temocillin, a narrow-spectrum penicillin stable to many beta-lactamases , against V. choleraeobtained from patients suffering of cholera and submitted to the national reference health laboratory of Iran. All isolates were collected consecutively and originated from 20 different provinces in Iran (Alborz, Busheher, Esfahan, Ghazvin, Gilan, Gonabad, Gorgan, Hormozgan, Jiroft, Kashmar,...
This investigation was funded by Belpharma S.A., Luxembourg.
Compliance with ethical standards
Conflict of interest
MR and MM have received sponsorship from Belpharma to attend scientific meetings. SVDV is an employee of Eumedica s.a. RS and MRF declare that they have no conflicts of interest.
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