Discordant isolates in bone specimens from patients with recurrent foot osteomyelitis

  • Neal R. BarshesEmail author
  • Cezarina Mindru
  • Barbara W. Trautner
  • Maria C. Rodriguez-Barradas
Original Article


We compared paired operative bone cultures (initial operation and reoperation) for 35 patients who experienced foot osteomyelitis treatment failure at a single hospital. Concordance was poor (kappa = 0.180). Staphylococcus aureus, gram negatives, and anaerobes were the most common discordant bacteria seen at reoperation, while Enterococcus was the most persistent.


Diabetic foot infection Osteomyelitis Bone biopsy 



Dr. Neal Barshes would like to acknowledge research funding from the Michael E. DeBakey Veterans Affairs Medical Medical Affairs Center and the Michael E. DeBakey Department of Surgery at Baylor College of Medicine.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This project was approved by the Baylor College of Medicine Institutional Review Board (protocol H-34858) and by the Michael E. DeBakey Veterans Affairs Medical Center Research Committee (protocol 15A12.HB). All research was consistent with principles outlined in the Helsinki Declaration.

Informed consent

Individual consent was not obtained for this study, as it was a retrospective review.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Vascular Surgery and Endovascular Therapy, Michael E. Debakey Department of SurgeryBaylor College of MedicineHoustonUSA
  2. 2.Michael E. DeBakey Veterans Affairs Medical CenterHoustonUSA
  3. 3.Division of Infectious Diseases, Department of MedicineBaylor College of MedicineHoustonUSA

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