Discordant isolates in bone specimens from patients with recurrent foot osteomyelitis
We compared paired operative bone cultures (initial operation and reoperation) for 35 patients who experienced foot osteomyelitis treatment failure at a single hospital. Concordance was poor (kappa = 0.180). Staphylococcus aureus, gram negatives, and anaerobes were the most common discordant bacteria seen at reoperation, while Enterococcus was the most persistent.
KeywordsDiabetic foot infection Osteomyelitis Bone biopsy
Dr. Neal Barshes would like to acknowledge research funding from the Michael E. DeBakey Veterans Affairs Medical Medical Affairs Center and the Michael E. DeBakey Department of Surgery at Baylor College of Medicine.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This project was approved by the Baylor College of Medicine Institutional Review Board (protocol H-34858) and by the Michael E. DeBakey Veterans Affairs Medical Center Research Committee (protocol 15A12.HB). All research was consistent with principles outlined in the Helsinki Declaration.
Individual consent was not obtained for this study, as it was a retrospective review.
- 11.Kalan L, Loesche M, Hodkinson BP, Heilmann K, Ruthel G, Gardner SE, Grice EA (2016) Redefining the chronic-wound microbiome: fungal communities are prevalent, dynamic, and associated with delayed healing. MBio 7(5):e01058-16. https://doi.org/10.1128/mBio.01058-16