Alternative switching strategies based on regimens with a low genetic barrier: do clinicians have a choice nowadays?

  • Jesús TroyaEmail author
  • Pablo Ryan
  • Rocío Montejano
  • Alfonso Cabello
  • Guillermo Cuevas
  • Mariano Matarranz
  • Irene Cañamares
  • Javier Solís
  • Luis Álvarez-Sala Walther


Clinicians sometimes use switching strategies based on regimens such as RAL + ABC/3TC or RPV + ABC/3TC in order to resolve tolerability or safety issues associated with conventional recommended first-line strategies. Despite the low genetic barrier of these regimens, high safety and efficacy rates have been reported in retrospective studies.


Switching Raltegravir Rilpivirine Abacavir/lamivudine Safety Efficacy 


Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Ethical approval has not been necessary as this article is based on a review of published data.

Informed consent

Informed consent has not been necessary as this article is based on a review of published data.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jesús Troya
    • 1
    • 2
    Email author
  • Pablo Ryan
    • 1
    • 2
  • Rocío Montejano
    • 3
  • Alfonso Cabello
    • 4
  • Guillermo Cuevas
    • 1
  • Mariano Matarranz
    • 1
  • Irene Cañamares
    • 1
  • Javier Solís
    • 1
  • Luis Álvarez-Sala Walther
    • 2
    • 5
  1. 1.Hospital Universitario Infanta LeonorMadridSpain
  2. 2.School of MedicineUniversidad Complutense de MadridMadridSpain
  3. 3.Hospital Universitario La PazMadridSpain
  4. 4.Hospital Fundación Jiménez DíazMadridSpain
  5. 5.Hospital Universitario Gregorio MarañónMadridSpain

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