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Chromosomally encoded and plasmid-mediated polymyxins resistance in Acinetobacter baumannii: a huge public health threat

  • William Gustavo Lima
  • Mara Cristina Alves
  • Waleska Stephanie Cruz
  • Magna Cristina Paiva
Review

Abstract

Acinetobacter baumannii is an opportunistic pathogen associated with nosocomial and community infections of great clinical relevance. Its ability to rapidly develop resistance to antimicrobials, especially carbapenems, has re-boosted the prescription and use of polymyxins. However, the emergence of strains resistant to these antimicrobials is becoming a critical issue in several regions of the world because very few of currently available antibiotics are effective in these cases. This review summarizes the most up-to-date knowledge about chromosomally encoded and plasmid-mediated polymyxins resistance in A. baumannii. Different mechanisms are employed by A. baumannii to overcome the antibacterial effects of polymyxins. Modification of the outer membrane through phosphoethanolamine addition, loss of lipopolysaccharide, symmetric rupture, metabolic changes affecting osmoprotective amino acids, and overexpression of efflux pumps are involved in this process. Several genetic elements modulate these mechanisms, but only three of them have been described so far in A. baumannii clinical isolates such as mutations in pmrCAB, lpxACD, and lpsB. Elucidation of genotypic profiles and resistance mechanisms are necessary for control and fight against resistance to polymyxins in A. baumannii, thereby protecting this class for future treatment.

Keywords

Outer membrane Lipid A Phosphoethanolamine transferase Efflux pumps Osmoprotective amino acids mcr 

Notes

Acknowledgements

We thank UFSJ/PPGCF for the availability of bibliographic support. W.G.L. is grateful to Fundação de Amparo à Pesquisa de Minas Gerais (FAPMIG) for a graduate fellowship.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Laboratory of Medical Microbiology, Central-West Campus Dona LinduFederal University of São João del-ReiDivinopolisBrazil
  2. 2.Laboratory of Laboratorial Diagnostic and Clinical Microbiology, Central-West Campus Dona LinduFederal University of São João del-ReiDivinopolisBrazil
  3. 3.Laboratory of Molecular and Celular Biology, Alto Paraopeba CampusFederal University of São João del-ReiOuro BrancoBrazil

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