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Pharmacokinetic considerations in selecting optimal antibiotic therapy for Mycoplasma pneumoniae encephalitis

  • Burke A. CunhaEmail author
  • Cheston B. Cunha
Review
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Abstract

Effective antimicrobial therapy depends on several factors including degree of activity against the pathogen, antibiotic resistance, and when relevant, optimal tissue penetration factors. Central nervous system (CNS) infections illustrate these points well. The pharmacokinetic (PK) parameters important in antibiotic blood cerebrospinal fluid barrier (BCB) penetration that is important in meningitis are different and do not predict blood brain barrier (BBB) penetration. Recently, we had a case of Mycoplasma pneumoniae encephalitis (MPE) which prompted a review of the antibiotic PK determinants of BBB penetration which differ markedly from those of BCB penetration important in encephalitis. Using MPE as an illustrative example, this article reviews host and drug factors of therapeutic importance in optimally treating MPE.

Keywords

CNS manifestations of Mycoplasma pneumoniae Blood brain barrier (BBB) Antibiotic lipid solubility Tissue penetration of hydrophilic and hydrophilic antibiotics Antibiotic penetration across brain barrier (BPB) 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Infectious Disease DivisionNYU Winthrop HospitalMineolaUSA
  2. 2.School of MedicineState University of New YorkNew YorkUSA
  3. 3.Division of Infectious DiseaseRhode Island Hospital and The Miriam HospitalProvidenceUSA
  4. 4.Brown University Alpert School of MedicineProvidenceUSA

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