Early double J stent removal in renal transplant patients to prevent urinary tract infection – systematic review and meta-analysis of randomized controlled trials

  • Dafna Yahav
  • Hefziba Green
  • Noa Eliakim-Raz
  • Eytan Mor
  • Shahid Husain
Original Article
  • 135 Downloads

Abstract

Ureteral stents are routinely used in renal transplant and are associated with reduced urological complications but increased urinary tract infections (UTIs). There is no agreement on the preferred time to removal of stents after transplantation. We performed a systematic review and meta-analysis of all randomized controlled trials (RCTs) comparing stent duration of <14 days vs > =14 days. Electronic databases were searched to identify RCTs that compared early vs late stent removal. Primary outcome was urinary tract infections. Secondary outcomes included various urological complications. No significant difference in UTI rates was demonstrated between short and long stent duration (relative risk (RR) 0.85, 95% confidence interval (CI) 0.44–1.64), with significant heterogeneity (I2 = 86%). Sensitivity analysis evaluating studies with low risk of bias for allocation concealment demonstrated statistically significant lower rates of UTI with short stent duration (RR 0.48, 95% CI 0.32–0.71) with no heterogeneity. No significant difference was demonstrated for the outcome of major urological complications (RR 0.72, 95% CI 0.50–1.05), without heterogeneity. Ureteral stenosis rates were significantly lower in the short duration arm (RR 0.42, 95% CI 0.18–0.98). Early removal of ureteral stents after renal transplant may be associated with reduced rates of UTI and ureteral stenosis. Additional RCTs are needed.

Notes

Compliance with ethical standards

Conflict of interest

All authors declare no conflict of interest. The results presented in this paper have not been published previously in whole or part.

Ethical approval

Not necessary.

Informed consent

Irrelevant due to study design.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Dafna Yahav
    • 1
    • 2
  • Hefziba Green
    • 2
    • 3
  • Noa Eliakim-Raz
    • 1
    • 2
  • Eytan Mor
    • 2
    • 4
  • Shahid Husain
    • 5
  1. 1.Infectious Diseases Unit, Rabin Medical CenterBeilinson HospitalPetah-TikvaIsrael
  2. 2.Sackler Faculty of MedicineTel Aviv UniversityRamat AvivIsrael
  3. 3.Department of Nephrology and Hypertension and Medicine B, Rabin Medical CenterBeilinson HospitalPetah TikvaIsrael
  4. 4.Department of Transplantation, Rabin Medical CenterBeilinson HospitalPetah TikvaIsrael
  5. 5.Multi-organ Transplant Program, Infectious Diseases Division, University Health NetworkUniversity of TorontoTorontoCanada

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