Demonstration of the herd effect in adults after the implementation of pneumococcal vaccination with PCV13 in children

  • C. Hays
  • Q. Vermee
  • A. Agathine
  • A. Dupuis
  • E. Varon
  • C. Poyart
  • M.-C. Ploy
  • J. Raymond
  • and the ORP Ile de France Ouest
Original Article


The purpose of this investigation was to describe the evolution of serotypes and antibiotic susceptibility of Streptococcus pneumoniae strains isolated from both adults and children from the same population area with invasive pneumococcal disease (IPD) or acute otitis media (AOM), 5 years after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). From 2009 to 2015, 839 strains of S. pneumoniae strains were collected (481 from adults and 358 from children). Serotyping by latex antisera and molecular methods was performed. Antimicrobial susceptibility was tested. Compared to 2009, the total number of strains isolated in 2015 decreased in children (263 vs. 53, respectively) and in adults (220 vs. 131, respectively). Serotype coverage of PCV13 for IPD decreased significantly in adults from 67.7% (149/220) to 25.2% (33/131) and in children from 75.1% (61/81) to 18.5% (5/27). Especially, serotypes 1, 7F and 19A decreased significantly in children, while serotypes 7F and 19A decreased significantly in adults. PCV13 serotypes involved in AOM decreased significantly over the 5-year period, from 85.7% (156/182) to 38.5% (10/26), and were more susceptible to penicillin, amoxicillin and cefotaxime, p < 0.05. Serotypes 8, 9N and 10A seemed to emerge in adults, whereas any serotype prevalence was observed in children. Between 2009 and 2015, the introduction of PCV13 has resulted in a significant decrease of the number of S. pneumoniae strains isolated from IPD in children as in adults. It highlights a strong herd effect of vaccination in adults.


Cefotaxime Acute Otitis Medium Invasive Pneumococcal Disease Herd Effect Recurrent Acute Otitis Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We sincerely thank all the members of the ORP Ile de France Ouest for the data collection: G. Arlet, L. Armand-Lefevre, E. Benabib, T. Billard-Pomares, G. Blanchard, E. Cambau, E. Carrer-Causseret, C. Doit, A. Claudinon, F. Doucet-Populaire, Agnès Ferroni, C. Freneaux, C. Guillet-Caruba, H. Lecuyer, V. Leflon-Guibout, M. Leneveu, Françoise Leturdu, A.C. Maherault, D. Moissenet, A. Mbadi, L. Raskine, F. Richardin, V. Sivadon-Tardy, C. Souffi, J. Tankovic, C. Verdet.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

For this type of retrospective study, informed consent is not required.

Ethical approval

Isolates were stored and data were anonymised. Therefore, development of the typing scheme on stored and anonymised isolates in a retrospective study did not require ethical approval.


No grant was received for this study.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • C. Hays
    • 1
  • Q. Vermee
    • 1
  • A. Agathine
    • 1
  • A. Dupuis
    • 1
  • E. Varon
    • 2
  • C. Poyart
    • 1
  • M.-C. Ploy
    • 3
  • J. Raymond
    • 1
  • and the ORP Ile de France Ouest
  1. 1.University Paris 5, Hôpital Cochin, BacteriologieParisFrance
  2. 2.University Paris 5, Hôpital Georges Pompidou, CNR PneumocoquesParis 15France
  3. 3.Observatoire Regional des PneumocoquesLaboratoire de Bactériologie-Virologie-Hygiène, CHU Dupuytrein87042 LimogesFrance

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