An estimate of the burden of serious fungal diseases in Greece
- 291 Downloads
Data on the epidemiology of serious fungal infections in Greece are scarce. Our aim was to calculate the burden of serious fungal diseases in Greece. A thorough literature search for papers reporting epidemiological data on serious fungal diseases in Greece was performed. Where no Greek data existed, we used a structured set of assumptions to estimate fungal disease burden, based on specific high-risk populations. Of the 10.8 million population, 85.5 % are adults and 27 % are over 60 years of age. The annual fungal disease estimates are as follows: 142,337 Greek women get recurrent vaginal thrush (2,632 cases/100,000 females); there are 889 cases of esophageal candidiasis (8.2 cases/100,000); annual incidence of Pneumocystis pneumonia is 112 cases; chronic pulmonary aspergillosis prevalence is 386 cases; there are 20,843 patients with allergic bronchopulmonary aspergillosis and 27,744 with severe asthma with fungal sensitization; candidaemia incidence is 541 cases (5.0/100,000); there are 81 cases of Candida peritonitis; invasive aspergillosis occurs in 1,125 patients. According to our calculations, 194,067 individuals (1.79 cases/100,000) in Greece suffer from serious fungal diseases each year. This is the first attempt to determine the burden of fungal diseases in Greece, and provides a crude estimate on its impact on public health.
Compliance with ethical standards
This work was partly supported by the Special Account for Research Grants (ELKE) of the National and Kapodistrian University of Athens [grant number 70/3/11724].
Conflict of Interest
The authors declare that they have no conflict of interest related to this research.
Research involving human participants and/or animals
This article does not contain any studies with human participants or animals performed by any of the authors.
For this type of study, formal consent is not required.
- 9.Spyrou AN (2009) Epidemiological study of leukemia incidence and mortality in the Greek population. Dissertation, Thessaloniki Aristotle UniversityGoogle Scholar
- 23.Gamaletsou MN, Sipsas NV, Kontoyiannis DP, Tsiakalos A, Kontos AN, Stefanou I et al (2012) Successful salvage therapy of refractory HIV-related cryptococcal meningitis with the combination of liposomal amphotericin B, voriconazole, and recombinant interferon-γ. Diagn Microbiol Infect Dis 74:409–411CrossRefPubMedGoogle Scholar
- 29.Zervas E, Loukides S, Kostikas K, Bakakaos P, Tzortzaki E, Gaga M, on behalf of Asthma Working Group of Hellenic Thoracic Society (2012) Asthma and asthma-like symptoms in Greece. The Greece asthma national prevalence survey. European Respiratory Society Annual Congress, September 1–5, 2012; Vienna, Austria, abstract P3936Google Scholar
- 39.Perkhofer S, Lass-Flörl C, Hell M, Russ G, Krause R, Hönigl M et al (2010) The Nationwide Austrian Aspergillus Registry: a prospective data collection on epidemiology, therapy and outcome of invasive mould infections in immunocompromised and/or immunosuppressed patients. Int J Antimicrob Agents 36:531–536CrossRefPubMedGoogle Scholar
- 40.Apostolidi EA, Gamaletsou MN, Markogiannakis A, Sipsas NV (2016) Epidemiology and outcome of invasive aspergillosis in patients with hematological malignancies: a Greek, single center, prospective, observational study (2014–2015). 7th Advances Against Aspergillosis Conference; 3–5 March 2016, Manchester, UK, abstract # P95Google Scholar
- 45.Drogari-Apiranthitou M, Skiada A, Petrikkos G (2016) Epidemiology of mucormycosis in Greece; results from a 10-year multicentre nationwide survey. 26th European Congress of Clinical Microbiology and Infectious Diseases, 9–12 April 2016, Amsterdam, Nederland, Abstract #P0371Google Scholar