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Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014

  • L. Huang
  • X. Luo
  • J. Shao
  • H. Yan
  • Y. Qiu
  • P. Ke
  • W. Zheng
  • B. Xu
  • W. Li
  • D. Sun
  • D. Cao
  • C. Chen
  • F. Zhuo
  • X. Lin
  • F. Tang
  • B. Bao
  • Y. Zhou
  • X. Zhang
  • H. Li
  • J. Li
  • D. Wan
  • L. Yang
  • Y. Chen
  • Q. Zhong
  • X. Gu
  • J. Liu
  • L. Huang
  • R. Xie
  • X. Li
  • Y. Xu
  • Z. Luo
  • M. Liao
  • H. Wang
  • L. Sun
  • H. Li
  • G. W. Lau
  • C. DuanEmail author
Original Article

Abstract

Dengue is a rapidly spreading mosquito-borne disease caused by the dengue virus (DENV) and has emerged as a severe public health problem around the world. Guangdong, one of the southern Chinese provinces, experienced a serious outbreak of dengue in 2014, which was believed to be the worst dengue epidemic in China over the last 20 years. To better understand the epidemic, we collected the epidemiological data of the outbreak and analyzed 14,594 clinically suspected dengue patients from 25 hospitals in Guangdong. Dengue cases were then laboratory-confirmed by the detection of DENV non-structural protein 1 (NS1) antigen and/or DENV RNA. Afterwards, clinical manifestations of dengue patients were analyzed and 93 laboratory-positive serum specimens were chosen for the DENV serotyping and molecular analysis. Our data showed that the 2014 dengue outbreak in Guangdong had spread to 20 cities and more than 45 thousand people suffered from dengue fever. Of 14,594 participants, 11,387 were definitively diagnosed. Most manifested with a typical non-severe clinical course, and 1.96 % developed to severe dengue. The strains isolated successfully from the serum samples were identified as DENV-1. Genetic analyses revealed that the strains were classified into genotypes I and V of DENV-1, and the dengue epidemic of Guangdong in 2014 was caused by indigenous cases and imported cases from the neighboring Southeast Asian countries of Malaysia and Singapore. Overall, our study is informative and significant to the 2014 dengue outbreak in Guangdong and will provide crucial implications for dengue prevention and control in China and elsewhere.

Keywords

Dengue Virus Dengue Hemorrhagic Fever Dengue Infection Southeast Asian Country DENV Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank all the participants who consented to take part in this study, as well as the doctors and nurses for recruitment. Especially, we sincerely thank the laboratory technicians from the 25 hospitals who helped us collect and interpret the data.

Compliance with ethical standards

Conflict of interest

None declared.

Funding

This work was supported by the Guangdong Natural Science Foundation (grant number S2013010014007, 2014A030313070) and Guangdong Province Science & Technology Project Plan & Social Development Foundation (grant number 2010A030400006).

Supplementary material

10096_2015_2540_MOESM1_ESM.doc (32 kb)
Table S1 (DOC 32 kb)
10096_2015_2540_MOESM2_ESM.doc (83 kb)
Table S2 (DOC 83 kb)
10096_2015_2540_Fig3_ESM.gif (30 kb)
Fig. S1

The workflow of clinical data collection from 25 hospitals in Guangdong (GIF 29 kb)

10096_2015_2540_MOESM3_ESM.tiff (6.6 mb)
High-resolution image (TIFF 6796 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • L. Huang
    • 1
    • 2
  • X. Luo
    • 1
    • 2
  • J. Shao
    • 1
    • 3
  • H. Yan
    • 1
    • 2
  • Y. Qiu
    • 4
  • P. Ke
    • 5
  • W. Zheng
    • 6
  • B. Xu
    • 7
  • W. Li
    • 8
  • D. Sun
    • 4
  • D. Cao
    • 9
  • C. Chen
    • 10
  • F. Zhuo
    • 11
  • X. Lin
    • 12
  • F. Tang
    • 13
  • B. Bao
    • 14
  • Y. Zhou
    • 15
  • X. Zhang
    • 16
  • H. Li
    • 17
  • J. Li
    • 18
  • D. Wan
    • 19
  • L. Yang
    • 20
  • Y. Chen
    • 21
  • Q. Zhong
    • 22
  • X. Gu
    • 23
  • J. Liu
    • 24
  • L. Huang
    • 25
  • R. Xie
    • 26
  • X. Li
    • 27
  • Y. Xu
    • 1
    • 2
  • Z. Luo
    • 1
    • 2
  • M. Liao
    • 1
    • 2
  • H. Wang
    • 1
    • 2
  • L. Sun
    • 1
    • 2
  • H. Li
    • 1
    • 2
  • G. W. Lau
    • 28
  • C. Duan
    • 1
    • 2
    Email author
  1. 1.Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouPeople’s Republic of China
  2. 2.Department of Clinical Laboratory, Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouPeople’s Republic of China
  3. 3.Medical Research Center, Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouPeople’s Republic of China
  4. 4.Laboratory Medicine Center, Nanfang HospitalSouthern Medical UniversityGuangzhouPeople’s Republic of China
  5. 5.Department of Clinical LaboratoryGuangdong Provincial Hospital of Chinese MedicineGuangzhouPeople’s Republic of China
  6. 6.Department of Clinical Laboratory, Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouPeople’s Republic of China
  7. 7.Department of Laboratory MedicineGuangzhou First Municipal People’s Hospital, Affiliated Hospital of Guangzhou Medical CollegeGuangzhouPeople’s Republic of China
  8. 8.Department of Clinical LaboratoryThe First People’s Hospital of FoshanFoshanPeople’s Republic of China
  9. 9.Department of Laboratory MedicineGuangdong No.2 Provincial People’s HospitalGuangzhouPeople’s Republic of China
  10. 10.Department of Clinical LaboratoryZhanjiang Center People’s HospitalZhanjiangPeople’s Republic of China
  11. 11.Luohu District Center for Disease Control and PreventionShenzhenPeople’s Republic of China
  12. 12.Department of Clinical LaboratoryShantou Central HospitalShantouPeople’s Republic of China
  13. 13.Department of Clinical Laboratory, Zhuhai People’s HospitalZhuhai Hospital of Jinan UniversityZhuhaiChina
  14. 14.Department of Clinical Laboratory12th Guangzhou People’s HospitalGuangzhouPeople’s Republic of China
  15. 15.Department of Clinical LaboratoryGuangzhou Xinhai HospitalGuangzhouPeople’s Republic of China
  16. 16.Department of Laboratory Diagnosis, Sun Yat-sen University Affiliated Zhongshan HospitalSun Yat-sen UniversityZhongshanChina
  17. 17.Department of Clinical LaboratoryZhaoqing People’s HospitalZhaoqingChina
  18. 18.Department of Clinical LaboratoryQingyuan People’s HospitalQingyuanChina
  19. 19.Department of Clinical LaboratoryDongguan People’s HospitalDongguanChina
  20. 20.Department of Clinical LaboratoryChaozhou Central HospitalChaozhouChina
  21. 21.Department of Clinical LaboratoryMaoming People’s HospitalMaomingChina
  22. 22.Department of Clinical LaboratoryJieyang People’s HospitalJieyangChina
  23. 23.Department of Clinical LaboratoryHeyuan People’s HospitalHeyuanChina
  24. 24.Department of Clinical LaboratoryHuizhou First Municipal People’s HospitalHuizhouChina
  25. 25.Department of Clinical LaboratoryShaoguan People’s HospitalShaoguanChina
  26. 26.Department of Clinical LaboratoryYunfu People’s HospitalYunfuChina
  27. 27.Department of Clinical LaboratoryShanwei Yihui Foundation HospitalShanweiChina
  28. 28.Department of PathobiologyUniversity of Illinois at Urbana-ChampaignUrbanaUSA

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