Influenza vaccination: a summary of Cochrane Reviews

  • S. F. ØsterhusEmail author


The Cochrane Library was systematically searched for meta-analyses regarding influenza vaccination of various populations, both healthy and sick. An effect in reducing the number of cases of influenza, influenza-like illness or complications to influenza was found in some studies, but, generally, the quality of the studies was low, and several studies lacked hard clinical endpoints. Data on adverse effects were scarce. More randomised controlled trials investigating the effects of influenza vaccination are warranted.


Chronic Obstructive Pulmonary Disease Influenza Cystic Fibrosis Influenza Vaccine Cochrane Review 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest

This study received no funding or grants. The author has no commercial relationships and no potential conflicts of interest.


  1. 1.
    Federal Institute for Medical Technology—evaluation (2000) Influenza vaccination of the elderly (in Danish)Google Scholar
  2. 2.
    Centers for Disease Control and Prevention (CDC) Influenza vaccination: a summary for clinicians. Available online at: Accessed 9 Jun 2014
  3. 3.
    Osterholm MT, Kelley NS, Sommer A, Belongia EA (2012) Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect Dis 12(1):36–44. doi: 10.1016/S1473-3099(11)70295-X CrossRefPubMedGoogle Scholar
  4. 4.
    Remschmidt C, Wichmann O, Harder T (2014) Methodological quality of systematic reviews on influenza vaccination. Vaccine 32(15):1678–1684. doi: 10.1016/j.vaccine.2014.01.060 CrossRefPubMedGoogle Scholar
  5. 5.
    Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C, Porter AC, Tugwell P, Moher D, Bouter LM (2007) Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 7:10. doi: 10.1186/1471-2288-7-10 CrossRefPubMedCentralPubMedGoogle Scholar
  6. 6.
    Jefferson T, Rivetti A, Di Pietrantonj C, Demicheli V, Ferroni E (2012) Vaccines for preventing influenza in healthy children. Cochrane Database Syst Rev 8:CD004879. doi: 10.1002/14651858.CD004879.pub4
  7. 7.
    Demicheli V, Jefferson T, Al-Ansary LA, Ferroni E, Rivetti A, Di Pietrantonj C (2014) Vaccines for preventing influenza in healthy adults. Cochrane Database Syst Rev 3:CD001269. doi: 10.1002/14651858.CD001269.pub5
  8. 8.
    Jefferson T, Di Pietrantonj C, Al-Ansary LA, Ferroni E, Thorning S, Thomas RE (2010) Vaccines for preventing influenza in the elderly. Cochrane Database Syst Rev 2:CD004876Google Scholar
  9. 9.
    Thomas RE, Jefferson T, Lasserson TJ (2013) Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions. Cochrane Database Syst Rev 7:CD005187. doi: 10.1002/14651858.CD005187.pub4
  10. 10.
    Poole PJ, Chacko E, Wood-Baker RW, Cates CJ (2006) Influenza vaccine for patients with chronic obstructive pulmonary disease. Cochrane Database Syst Rev 1:CD002733Google Scholar
  11. 11.
    Cates CJ, Rowe BH (2013) Vaccines for preventing influenza in people with asthma. Cochrane Database Syst Rev 2:CD000364. doi: 10.1002/14651858.CD000364.pub4
  12. 12.
    Dharmaraj P, Smyth RL (2014) Vaccines for preventing influenza in people with cystic fibrosis. Cochrane Database Syst Rev 3:CD001753. doi: 10.1002/14651858.CD001753.pub3
  13. 13.
    Chang CC, Morris PS, Chang AB (2007) Influenza vaccine for children and adults with bronchiectasis. Cochrane Database Syst Rev 3:CD006218Google Scholar
  14. 14.
    Goossen GM, Kremer LCM, van de Wetering MD (2013) Influenza vaccination in children being treated with chemotherapy for cancer. Cochrane Database Syst Rev 8:CD006484. doi: 10.1002/14651858.CD006484.pub3
  15. 15.
    Eliakim-Raz N, Vinograd I, Zalmanovici Trestioreanu A, Leibovici L, Paul M (2013) Influenza vaccines in immunosuppressed adults with cancer. Cochrane Database Syst Rev 10:CD008983. doi: 10.1002/14651858.CD008983.pub2
  16. 16.
    Cheuk DK, Chiang AK, Lee TL, Chan GC, Ha SY (2011) Vaccines for prophylaxis of viral infections in patients with hematological malignancies. Cochrane Database Syst Rev 3:CD006505Google Scholar
  17. 17.
    Keller T, Weeda VB, van Dongen CJ, Levi M (2008) Influenza vaccines for preventing coronary heart disease. Cochrane Database Syst Rev 3:CD005050Google Scholar
  18. 18.
    Jackson LA, Nelson JC, Benson P, Neuzil KM, Reid RJ, Psaty BM, Heckbert SR, Larson EB, Weiss NS (2006) Functional status is a confounder of the association of influenza vaccine and risk of all cause mortality in seniors. Int J Epidemiol 35(2):345–352CrossRefPubMedGoogle Scholar
  19. 19.
    Jackson LA, Jackson ML, Nelson JC, Neuzil KM, Weiss NS (2006) Evidence of bias in estimates of influenza vaccine effectiveness in seniors. Int J Epidemiol 35(2):337–344CrossRefPubMedGoogle Scholar
  20. 20.
    Nelson JC, Jackson ML, Weiss NS, Jackson LA (2009) New strategies are needed to improve the accuracy of influenza vaccine effectiveness estimates among seniors. J Clin Epidemiol 62(7):687–694CrossRefPubMedGoogle Scholar
  21. 21.
    Jackson ML, Nelson JC (2013) The test-negative design for estimating influenza vaccine effectiveness. Vaccine 31(17):2165–2168CrossRefPubMedGoogle Scholar
  22. 22.
    Beyer WE, McElhaney J, Smith DJ, Monto AS, Nguyen-Van-Tam JS, Osterhaus AD (2013) Cochrane re-arranged: support for policies to vaccinate elderly people against influenza. Vaccine 31(50):6030–6033. doi: 10.1016/j.vaccine.2013.09.063 CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.General Practice Research UnitUniversity of CopenhagenMariboDenmark

Personalised recommendations