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Scalp eschar and neck lymphadenopathy after tick bite: an emerging syndrome with multiple causes

  • G. Dubourg
  • C. Socolovschi
  • P. Del Giudice
  • P. E. Fournier
  • D. RaoultEmail author
Article

Abstract

The clinical and epidemiological features of 56 patients with scalp eschar associated with neck lymphadenopathy after a tick bite (SENLAT) syndrome were evaluated at the National French Rickettsial Center. Eschar swabs, crusts, and biopsies as well as ticks and blood samples were acquired for molecular and serological assays. SENLAT predominantly affects children (p < 0.05), followed by 40- to 70-year-olds, and it is found mostly in women (p < 0.05). The seasonal distribution has two peaks: one in the spring (55%) and one in the autumn (30%). The etiological agent was identified in 18 cases, which include Rickettsia slovaca in 13 cases with incidences of two co-infections with Rickettsia raoultii and one case caused by Rickettsia sibirica mongolitimonae. Other possible agents that were found in attached ticks were Candidatus R. rioja, Coxiella burnetii, and Borrelia burgdorferi. The tick vector was Dermacentor marginatus in almost all cases, with the exception of one case, in which Ixodes ricinus was identified as the vector. Our findings show that SENLAT is a clinical entity characterized as a local infection controlled by the immune system and is neither pathogen- nor vector-specific.

Keywords

Borrelia Burgdorferi Francisella Tularensis Tick Bite Coxiella Burnetii Ixodes Ricinus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

We would like to thank Dr Duclos Casalongo for the photos.

Funding source

IHU Méditerranée Infection.

Transparency declaration

None to declare.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • G. Dubourg
    • 1
    • 2
  • C. Socolovschi
    • 1
    • 2
  • P. Del Giudice
    • 3
  • P. E. Fournier
    • 1
    • 2
  • D. Raoult
    • 1
    • 2
    • 4
    Email author
  1. 1.Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE; Research Unit on Infectious and Tropical Emerging Diseases) UM 63 CNRS 7278 IRD 198 INSERM U1095, Faculty of MedicineAix-Marseille UniversityMarseilleFrance
  2. 2.Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie-Hygiène-Virologie, University, Hospital Centre Timone, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Assistance PubliqueHôpitaux de MarseilleMarseilleFrance
  3. 3.Unité des Maladies Infectieuses et Dermatologie, Hôpital BonnetCentre Hospitalier Intercommunal de Fréjus–Saint-RaphaëlFréjus-Saint-RaphaëlFrance
  4. 4.URMITE – UMR CNRS 6236, IRD 198Faculté de MédecineMarseilleFrance

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