Prevalence and treatment of aerobic vaginitis among non-pregnant women: evaluation of the evidence for an underestimated clinical entity

  • G. S. Tansarli
  • E. K. Kostaras
  • S. Athanasiou
  • M. E. Falagas


We sought to evaluate the evidence on the prevalence of aerobic vaginitis (AV) among symptomatic non-pregnant women, as well as the treatment administered for this clinical entity. The PubMed and Scopus databases were systematically searched. Sixteen studies met the inclusion criteria, 11 of which reported on the prevalence of possible AV, two on the prevalence of diagnosed AV, and three on the treatment and outcomes of women with diagnosed AV. The prevalence of diagnosed AV varied from 5 to 10.5 %. Streptococcus spp., Staphylococcus aureus, and coagulase-negative staphylococci were the most commonly identified Gram-positive pathogens among women with possible AV, with prevalences of up to 58.7, 41.7, and 37.4 %, respectively, while Escherichia coli was the most common Gram-negative pathogen identified, with a prevalence of up to 23 % among symptomatic women. Regarding antibiotic treatment for AV, the antibiotic schemes administered, which mainly consisted of suppositories of aminoglycosides, showed good effectiveness without serious adverse events provided by any of the included studies. The currently available data suggest that the prevalence of AV is not negligible, while the prevalence of possible AV is considerable. Well-designed studies comparing the prevalence of aerobic pathogens between symptomatic and asymptomatic women are warranted.


Lactobacillus Bacterial Vaginosis Chlamydia Trachomatis Neisseria Gonorrhoeae Vaginitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest





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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • G. S. Tansarli
    • 1
  • E. K. Kostaras
    • 1
  • S. Athanasiou
    • 1
    • 3
  • M. E. Falagas
    • 1
    • 2
    • 4
  1. 1.Alfa Institute of Biomedical Sciences (AIBS)Marousi, AthensGreece
  2. 2.Department of Internal Medicine—Infectious DiseasesMitera Hospital, Hygeia GroupAthensGreece
  3. 3.Department of Obstetrics and GynecologyAthens University School of MedicineAthensGreece
  4. 4.Department of MedicineTufts University School of MedicineBostonUSA

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