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Impact of a computerized alert system for bacteremia notification on the appropriate antibiotic treatment of Staphylococcus aureus bloodstream infections

  • J. Kim
  • E.-J. Joo
  • Y. E. Ha
  • S. Y. Park
  • C.-I. Kang
  • D. R. Chung
  • J.-H. Song
  • K. R. PeckEmail author
Article

Abstract

A computerized alert system (CAS) has been introduced to notify bacteremia in real time. We evaluated the impact of the CAS on the administration of appropriate antibiotics in patients with Staphylococcus aureus bloodstream infections (BSIs). We retrospectively reviewed the medical records of patients with S. aureus BSI for each 1-year control and intervention periods, before and after the implementation of the CAS. The proportions of appropriate antibiotic treatment were compared between the control and intervention periods. The 30-day mortality of S. aureus bacteremia was also assessed in the study population. A total of 313 patients were included in the study. Appropriate antibiotics were initiated 7 h earlier in the intervention period (mean time, 13.5 h vs. 20.0 h; p = 0.136). The administration of appropriate antibiotics within the 24 h after blood acquisition was similar between the two periods, but this significantly increased from 3.3 % in the control period to 10.6 % in the intervention during the 24–36 h interval (p = 0.012). In the subgroup analysis, similar trends were observed in patients with methicillin-resistant isolates (6.7 % vs. 18.2 %; p = 0.032) and hospital-onset infection (3.5 % vs. 17.1 %; p = 0.004). The independent risk factors for 30-day mortality of S. aureus bacteremia were age, a high Pitt bacteremia score, an increased Charlson’s weighted index of comorbidity, and hospital-onset infection, although the appropriateness of antibiotic therapy within 36 h and the CAS were not identified as predictors. The CAS increased the proportion of appropriate antimicrobial therapy during the 24–36 h interval after bacteremia onset in patients with S. aureus BSIs.

Keywords

Control Period Positive Blood Culture Infectious Disease Specialist Antimicrobial Stewardship Program Automate Blood Culture System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Funding

This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (A102065).

Competing interests

None declared.

Ethical approval

Not required.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • J. Kim
    • 1
  • E.-J. Joo
    • 1
  • Y. E. Ha
    • 1
  • S. Y. Park
    • 1
  • C.-I. Kang
    • 1
  • D. R. Chung
    • 1
  • J.-H. Song
    • 1
  • K. R. Peck
    • 1
    Email author
  1. 1.Division of Infectious Diseases, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea

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