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The role of Streptococcus pneumoniae in community-acquired pneumonia among adults in Europe: a meta-analysis

  • M. H. Rozenbaum
  • P. Pechlivanoglou
  • T. S. van der Werf
  • J. R. Lo-Ten-Foe
  • M. J. Postma
  • E. Hak
Review

Abstract

The primary objective of this meta-analysis was to estimate the prevalence of adult community-acquired pneumonia (CAP) caused by Streptococcus pneumoniae in Europe, adjusted for possible independent covariates. Two reviewers conducted a systematic literature search using PubMed on English-language articles that involved human subjects with CAP during the period from January 1990 to November 2011 across European countries. A mixed-effects meta-regression model was developed and populated with 24,410 patients obtained from 77 articles that met the inclusion criteria. The model showed that the observed prevalence of S. pneumoniae in CAP significantly varies between European regions, even after adjusting for explanatory covariates, including patient characteristics, diagnostic tests, antibiotic resistance, and health-care setting. The probability of detecting S. pneumoniae was substantially higher in studies that performed more frequently a diagnostic polymerase chain reaction assay compared to all the other diagnostic tests included. Furthermore, S. pneumoniae was more likely to be confirmed as the cause of a CAP in studies with intensive care unit patients as compared to those with hospital- or community-treated patients. This study provides estimates of the average observed prevalence of S. pneumoniae, which could be used for projecting the health and economic benefits of pneumococcal immunization.

Keywords

Chronic Obstructive Pulmonary Disease Invasive Pneumococcal Disease Polymerase Chain Reaction Test Diagnostic Polymerase Chain Reaction Pneumococcal Immunization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • M. H. Rozenbaum
    • 1
  • P. Pechlivanoglou
    • 1
  • T. S. van der Werf
    • 2
  • J. R. Lo-Ten-Foe
    • 3
  • M. J. Postma
    • 1
  • E. Hak
    • 1
  1. 1.Unit of PharmacoEpidemiology & PharmacoEconomics , Department of PharmacyUniversity of GroningenGroningenThe Netherlands
  2. 2.Department of Internal Medicine and Pulmonary Diseases and TuberculosisUniversity Medical Center Groningen, University of GroningenGroningenThe Netherlands
  3. 3.Department of Medical Microbiology and Infection PreventionUniversity Medical Center Groningen, University of GroningenGroningenThe Netherlands

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