Listeriosis in pregnancy: a secular trend in a tertiary referral hospital in Barcelona

  • C. Sisó
  • A. Goncé
  • J. Bosch
  • M. D. Salvia
  • S. Hernández
  • F. Figueras


The purpose of this study was to describe the variation in listeriosis infection incidence during pregnancy over a 25-year period based on salient clinical and laboratory features compiled in a tertiary referral hospital and to depict the clinical characteristics of these cases. A cohort was created of all cases of listeriosis in pregnant women or their neonates (early-onset form) diagnosed between 1985 and 2010. Forty-three cases of perinatal listeriosis were diagnosed among the 82,320 hospitalised pregnant women (incidence 0.5‰). Whereas the incidence remained almost constant at 0.24‰ until 2000, an increasing incidence was observed from then on, reaching 0.86‰ during the last years of the study period. A four-fold increase in listeriosis rate during pregnancy has occurred in recent years, with poorer outcome for those cases occurring before 28 weeks and for those in which early antibiotic treatment was not provided. These results should raise the awareness of the agencies and professionals involved in prenatal care.


Listeria Neonatal Sepsis Chorioamnionitis Listeriosis Tertiary Referral Hospital 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank the Hospital obgyn residents, neonatologists and microbiologists for collecting patient data and processing the samples.

Conflict of interest statement

We declare that we have no conflict of interest.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  1. 1.Department of Maternal-Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i NeonatologiaHospital Clínic, University of BarcelonaBarcelonaSpain
  2. 2.BarcelonaSpain
  3. 3.Microbiology Service, Biomedical Diagnosis CentreHospital Clínic, University of BarcelonaBarcelonaSpain
  4. 4.Department of Neonatology, Institut Clinic de Ginecologia, Obstetricia i NeonatologiaHospital Clínic, University of BarcelonaBarcelonaSpain
  5. 5.LleidaSpain

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