Coagulase-negative staphylococci: update on the molecular epidemiology and clinical presentation, with a focus on Staphylococcus epidermidis and Staphylococcus saprophyticus

  • M. Widerström
  • J. Wiström
  • A. Sjöstedt
  • T. Monsen


Coagulase-negative staphylococci (CoNS), originally described as ubiquitous commensals of the healthy human skin and mucosa, have emerged as important opportunistic pathogens primarily causing healthcare-associated infections in patients with indwelling medical devices. Recent studies, utilizing new molecular typing methods, particularly on Staphylococcus epidermidis, have increased our understanding of the mechanisms that contribute to the evolutionary success of these extremely versatile microorganisms. In the following mini-review, we summarize recent research in this area focusing on the molecular methods and epidemiology of S. epidermidis and S. saprophyticus.


Amplify Fragment Length Polymorphism Molecular Epidemiology Shunt Infection Prosthetic Valve Endocarditis PFGE Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • M. Widerström
    • 1
    • 3
  • J. Wiström
    • 2
  • A. Sjöstedt
    • 3
  • T. Monsen
    • 3
  1. 1.Department of Infectious DiseasesÖstersund HospitalÖstersundSweden
  2. 2.Department of Infectious DiseasesUniversity Hospital of UmeåUmeåSweden
  3. 3.Department of Clinical BacteriologyUniversity Hospital of UmeåUmeåSweden

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