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Bacteremia caused by Brevundimonas species at a tertiary care hospital in Taiwan, 2000–2010

  • M. R. Lee
  • Y. T. Huang
  • C. H. Liao
  • T. Y. Chuang
  • C. K. Lin
  • S. W. Lee
  • C. C. Lai
  • C. J. Yu
  • P. R. Hsueh
Article

Abstract

We investigated clinical and microbiological characteristics of 30 patients with Brevundimonas bacteremia treated at a tertiary care hospital in Taiwan during 2000–2010. All the 30 bacteria isolates were confirmed to the species level by 16S rRNA sequencing analysis. Minimum inhibitory concentrations (MICs) of 11 antimicrobial agents against these isolates were determined by the agar dilution method. Seventeen (57%) patients had underlying malignancy, 12 (40%) had undergone central catheter placement, and 13 (43%) had received chemotherapy within the previous three months. Eight (27%) patients had community-acquired bacteremia and the remaining 22 patients (73%) had healthcare-associated bacteremia. The overall 14-day and 30-day mortality rates were 13% and 17%, respectively. Among the 30 isolates, B. vesicularis constituted most commonly (n = 22, 63%), followed by B. nasdae (n = 5) and B. diminuta (n = 3). All isolates were susceptible to piperacillin-tazobactam and amikacin, while all were resistant to ciprofloxacin and colistin. Tigecycline (MICs at which 90% of isolates are inhibited [MIC90] was 0.12 mg/L) and doripenem (MIC90 of 1 mg/L) both possessed good in vitro activities. In conclusions, Brevundimonas should be considered a pathogen that can cause bacteremia in immunocompromised hosts. Piperacillin-tazobactam, amikacin, doripenem, and tigecycline exhibit good in vitro activities against these ciprofloxacin- and colistin-resistant Brevundimonas species.

Keywords

Infective Endocarditis Colistin Cefepime Tigecycline Ertapenem 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Transparency declaration

All authors declare no conflicts of interest.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • M. R. Lee
    • 1
  • Y. T. Huang
    • 1
    • 5
  • C. H. Liao
    • 3
  • T. Y. Chuang
    • 2
  • C. K. Lin
    • 1
  • S. W. Lee
    • 2
  • C. C. Lai
    • 4
  • C. J. Yu
    • 1
  • P. R. Hsueh
    • 5
  1. 1.Department of Internal Medicine, National Taiwan University HospitalNational Taiwan University College of MedicineTaipeiTaiwan
  2. 2.Department of Internal MedicineTaoyuan General HospitalTaoyuanTaiwan
  3. 3.Department of Internal MedicineFar Eastern Memorial HospitalTaipeiTaiwan
  4. 4.Department of Intensive Care MedicineChi Mei Medical CenterTainanTaiwan
  5. 5.Department of Laboratory Medicine, National Taiwan University HospitalNational Taiwan University College of MedicineTaipeiTaiwan

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