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Human antimicrobial proteins in ear wax

  • M. Schwaab
  • A. Gurr
  • A. Neumann
  • S. Dazert
  • A. Minovi
Article

Abstract

The external auditory canal is vulnerable to bacterial infections, but little is known about thechemical compositions of ear wax regarding antimicrobial peptides. We, therefore, studied the proteinconcentrations of ten well-known human antimicrobial peptides from ear wax.Twenty ear wax samples from healthy individuals were analysed using enzyme-linked immunosorbent assay (ELISA) to determine theprotein concentrations of the antimicrobial peptides hBD1-3, lactoferrin, LL-37, BPI, hSLPI and HNP1-3. All ten antimicrobial peptides are present in ear wax. Some of these proteins seem to be merelycell-bound in ear wax. Antimicrobial peptides in ear wax prevent bacteria and fungi from causing infections inthe external auditory canal. The role and importance of these proteins for the blind-ending ear externalcanal is discussed. If this local defence system fails, infections of the external auditory canal may result.The knowledge about the presence of antimicrobial peptides in cerumen may lead to new concepts ofthe local treatment of external auditory canal diseases in the future.

Keywords

Antimicrobial Peptide External Auditory Canal Otitis Externa Human Lactoferrin Antimicrobial Potency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgement

Part of the data was reported at the annual meeting of the Association of Ear, Nose, and Throat Physicians of West Germany in Bochum, Germany, March 2010.

We thank Dr. med. M. D. Pearson for proofreading this manuscript and making corrections in his native language.

Conflict of interest

The authors have declared that no conflict of interest exists. There was no sponsorship or funding arrangements relating to the research.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • M. Schwaab
    • 1
    • 2
  • A. Gurr
    • 2
  • A. Neumann
    • 3
  • S. Dazert
    • 2
  • A. Minovi
    • 2
  1. 1.Department of Otorhinolarnygology, Head and Neck surgerySt. Marienhospital VechtaVechtaGermany
  2. 2.Department of Otorhinolarnygology, Head and Neck surgeryRuhr-University-BochumBochumGermany
  3. 3.Department for Ear-, Nose- and Throat-Disease, Head and Neck SurgeryLukaskrankenhausNeussGermany

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