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Posaconazole salvage treatment in paediatric patients: a multicentre survey

  • T. LehrnbecherEmail author
  • A. Attarbaschi
  • M. Duerken
  • J. Garbino
  • B. Gruhn
  • U. Kontny
  • S. Lüer
  • R. Phillips
  • J. Scholz
  • H. J. Wagner
  • T. Wiesel
  • A. H. Groll
Brief Report

Abstract

While a paediatric dosage has not been defined, posaconazole is occasionally being used in children. We conducted a multicentre retrospective survey and identified 15 patients (median age 10 years [range 3.6–17.5]) who received posaconazole salvage therapy for proven (9 patients) or probable (6 patients) invasive fungal infections. Posaconazole was administered for a median of 32 days (range 4–262) at a median dosage of 21 mg/kg (range 4.8–33.3). None of the patients discontinued therapy due to adverse events, which were mostly mild and observed in 11 patients. Complete or partial responses were observed in 4/7 patients with zygomycosis, 3/4 patients with invasive mould infection, 1/2 patients with invasive aspergillosis and 1/2 patients with chronic disseminated candidiasis. We conclude from the data that posaconazole displays favourable safety and tolerance and may be useful for management of individual paediatric patients with invasive infections.

Keywords

Invasive Aspergillosis Caspofungin Posaconazole Chronic Granulomatous Disease Invasive Fungal Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

TL has received grants from Gilead; he is a consultant to Gilead, Merck, Sharp & Dohme and Schering-Plough, and served at the speakers’ bureau of Astellas, Gilead, Merck, Sharp & Dohme and Schering-Plough. AHG has received grants from Gilead and Merck, Sharp & Dohme; he is a consultant to Astellas, Gilead, Merck, Sharp & Dohme and Schering-Plough, and has served at the speakers’ bureau of Astellas, Gilead, Merck, Sharp & Dohme, Pfizer, Schering-Plough and Zeneus/Cephalon. All other authors have nothing to declare.

Funding

None to declare.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • T. Lehrnbecher
    • 1
    Email author
  • A. Attarbaschi
    • 2
  • M. Duerken
    • 3
  • J. Garbino
    • 4
  • B. Gruhn
    • 5
  • U. Kontny
    • 6
  • S. Lüer
    • 7
  • R. Phillips
    • 8
  • J. Scholz
    • 9
  • H. J. Wagner
    • 10
  • T. Wiesel
    • 11
  • A. H. Groll
    • 12
  1. 1.Paediatric Haematology and Oncology, Children’s Hospital IIIJohann Wolfgang Goethe UniversityFrankfurtGermany
  2. 2.St. Anna Children’s HospitalViennaAustria
  3. 3.Children’s Hospital of MannheimMannheimGermany
  4. 4.Children’s Hospital of GenevaGenevaSwitzerland
  5. 5.Children’s Hospital of JenaJenaGermany
  6. 6.Children’s Hospital of FreiburgFreiburgGermany
  7. 7.Children’s Hospital of BernBernSwitzerland
  8. 8.Children’s Hospital of LeedsLeedsUK
  9. 9.Children’s Hospital of Frankfurt-HoechstFrankfurt-HoechstGermany
  10. 10.Children’s Hospital of GiessenGiessenGermany
  11. 11.Children’s Hospital of DattelnDattelnGermany
  12. 12.Children’s Hospital of MünsterMünsterGermany

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