First human isolates of methicillin-resistant Staphylococcus aureus sequence type 398 in Spain
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To the Editor,
An emerging sequence type (ST) 398 methicillin-resistant Staphylococcus aureus (MRSA) clone producing infections in humans has been detected across Europe . Recent studies indicate that it is widely distributed in farm animals, particularly in pigs, suggesting transmission between animals and humans .
The frequency of MRSA ST398 in the Spanish population is unknown. In this study, we present the first three human cases of MRSA ST398 infections admitted to two hospitals in the north-west of Spain.
Forty-four MRSA strains were isolated in 2006 in both hospitals. They were studied by the analysis of restriction fragment length polymorphism (RFLP) of the coagulase gene patterns and pulsed-field gel electrophoresis (PFGE) [3, 4]. Three non-Sma I typeable MRSA strains were identified; the three strains were EagI PFGE typeable. Next, they were analyzed by multilocus sequence typing (MLST) and spa typing [5, 6]. The staphylococcal chromosome cassette (SCC) mec, the...
KeywordsLevofloxacin Tobramycin Multilocus Sequence Typing PFGE Typeable ST398 Isolate
This work was supported by grants from Fondo de Investigaciones Sanitarias (07/0812) and Consellería de Sanidade (PS08/34), Spain.
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