Alternaria infectoria brain abscess in a child with chronic granulomatous disease

  • E. Hipolito
  • E. Faria
  • A. F. Alves
  • G. S. de Hoog
  • J. Anjos
  • T. Gonçalves
  • P. V. Morais
  • H. Estevão
Concise Article

Abstract

In the present report, we describe the first case of a phaeohyphomycotic brain abscess in a 5-year-old boy with chronic granulomatous disease (CGD) admitted to hospital with seizures. A computed tomography (CT) scan revealed a cerebral abscess and the microbiology study showed a dark, melanin-pigmented fungus, exhibiting only sterile hyphae. This fungus was identified by the amplification and sequencing of the 5.8S RNA gene and of the adjacent internal transcriber spacer domains, ITS1 and ITS2, as Alternaria infectoria. Due to the impossibility of a surgical excision, and although several therapeutic strategies were attempted, the patient died. Limitations in the routine identification procedures and therapeutic options of this emerging opportunistic agent are highlighted in this report.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • E. Hipolito
    • 1
  • E. Faria
    • 2
  • A. F. Alves
    • 3
  • G. S. de Hoog
    • 6
  • J. Anjos
    • 4
  • T. Gonçalves
    • 4
  • P. V. Morais
    • 5
  • H. Estevão
    • 1
  1. 1.Serviço de MedicinaHospital Pediátrico de CoimbraCoimbraPortugal
  2. 2.Consulta de Imunodeficiência PrimáriaHospital Pediátrico de CoimbraCoimbraPortugal
  3. 3.Laboratório de MicrobiologiaCentro Hospitalar de CoimbraCoimbraPortugal
  4. 4.Center for Neurosciences and Cell Biology, Instituto de MicrobiologiaFaculdade de Medicina da Universidade de CoimbraCoimbraPortugal
  5. 5.CIMAR Dept. of Bochemistry, FCTUCUniversity of CoimbraCoimbraPortugal
  6. 6.Centraalbureau voor SchimmelculturesUtrechtThe Netherlands

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