Detection of Pseudomonas aeruginosa producing metallo-β-lactamase VIM-2 in a central hospital from Portugal

  • A. Pena
  • A. M. Donato
  • A. F. Alves
  • R. Leitão
  • O. M. CardosoEmail author
Brief Report

Pseudomonas aeruginosa remains one of the most important pathogens in the nosocomial setting [1]. P. aeruginosa exhibits intrinsic resistance to several antimicrobial agents. The antipseudomonal β-lactams represent a major weapon against Pseudomonas infections, either for monotherapy or for combination therapy, for which β-lactams almost invariably represent one of the components. Therefore, resistance to these agents constitutes a major challenge for anti-Pseudomonas chemotherapy. Several mechanisms can contribute to β-lactam resistance in P. aeruginosa, including β-lactamase production, outer membrane impermeability and active efflux mediated by RND-type efflux systems [1]. During the last decade, the metallo-β-lactamases (MBLs) have emerged as new threatening mechanisms of broad-spectrum β-lactam resistance in P. aeruginosa. In fact, these enzymes can efficiently degrade virtually all antipseudomonal β-lactams (except aztreonam), while they are not susceptible to therapeutic...


Minimal Inhibitory Concentration Aztreonam Sentry Antimicrobial Surveillance Programme MicroScan WalkAway Combine Disk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank FCT through POCTI (FEDER) for financial support.

The authors thank Trindade Marques and Jorge Marques for their assistance with the data management.


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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • A. Pena
    • 1
  • A. M. Donato
    • 2
  • A. F. Alves
    • 3
  • R. Leitão
    • 1
  • O. M. Cardoso
    • 1
    Email author
  1. 1.Laboratory of Microbiology, Centro de Estudos Farmacêuticos, Faculty of PharmacyUniversity of CoimbraCoimbraPortugal
  2. 2.Laboratory of Clinical Analysis of the Faculty of PharmacyUniversity of CoimbraCoimbraPortugal
  3. 3.Laboratory of Microbiology, Centro Hospitalar de CoimbraCoimbraPortugal

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