Methicillin-susceptible, non-multiresistant methicillin-resistant and multiresistant methicillin-resistant Staphylococcus aureus infections: a clinical, epidemiological and microbiological comparative study

  • W. J. Munckhof
  • G. R. Nimmo
  • J. Carney
  • J. M. Schooneveldt
  • F. Huygens
  • J. Inman-Bamber
  • E. Tong
  • A. Morton
  • P. Giffard
Article

Abstract

Non-multiresistant methicillin-resistant Staphylococcus aureus (nmMRSA) infections are emerging worldwide and are often community-associated. This prospective case–cohort study compares features of 96 nmMRSA clinical isolates with 96 matched multiresistant MRSA (mMRSA) and 192 matched methicillin-susceptible S. aureus (MSSA) clinical isolates. Seventy-four percent of nmMRSA infections were healthcare-associated. nmMRSA infections were much more likely to involve skin and soft tissue (skin and soft tissue infections; SSTIs) and were much less likely to be treated appropriately with antibiotics than MSSA or mMRSA infections. Panton-Valentine leukocidin (PVL) genes were detected in 55% of nmMRSA, 16% of MSSA and 2% of mMRSA isolates. Independent of the methicillin-resistance phenotype, 59% of PVL-positive SSTIs presented as furunculosis compared to only 10% of PVL-negative SSTIs. Patients with PVL-positive infections were much younger than patients with PVL-negative infections. The proportion of PVL-positive infections peaked in the 10–29 years old age group, followed by a linear decline.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • W. J. Munckhof
    • 1
  • G. R. Nimmo
    • 2
  • J. Carney
    • 1
  • J. M. Schooneveldt
    • 2
  • F. Huygens
    • 3
  • J. Inman-Bamber
    • 3
  • E. Tong
    • 1
  • A. Morton
    • 1
  • P. Giffard
    • 3
  1. 1.Infection Management ServicePrincess Alexandra HospitalBrisbaneAustralia
  2. 2.Department of Microbiology, Qld Health Pathology Service (QHPS)Princess Alexandra HospitalBrisbaneAustralia
  3. 3.Cooperative Research Centre for DiagnosticsQueensland University of TechnologyBrisbaneAustralia

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