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The presence of infectious extracellular Francisella tularensis subsp. novicida in murine plasma after pulmonary challenge

  • J.-J. Yu
  • E. K. Raulie
  • A. K. Murthy
  • M. N. Guentzel
  • K. E. Klose
  • B. P. ArulanandamEmail author
Brief Report

Francisella tularensis is a gram-negative, facultative intracellular bacterium and is the causative agent of the zoonotic disease tularemia [1]. F. tularensis has been considered a potential biological weapon due to its low infectious dose and high mortality rate [2]. F. tularensis can be classified into several subspecies, including those relevant to human disease: F. tularensis subsp. tularensis (type A) and F. tularensis subsp. holarctica (type B); F. novicida and F. mediasiatica [3]. However, most of our knowledge about the pathogenesis of Francisella and the immune responses to the infection have come from studies of F. tularensis LVS (derived from holartica) and F. novicida [4, 5, 6]. Both organisms are attenuated in humans, while retaining virulence in mice. It is well established that Francisellaenters and replicates within host cells, and a strong research focus has been on deciphering the mechanisms for intramacrophage growth. However, little is known about the...

Keywords

Intracellular Bacterium Tularemia Francisella Tularensis Secondary Organ Tularensis Subsp 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by National Institutes of Health grant PO1 AI057986. The authors thank Michael Pammit from UTSA for technical expertise.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • J.-J. Yu
    • 1
  • E. K. Raulie
    • 1
  • A. K. Murthy
    • 1
  • M. N. Guentzel
    • 1
  • K. E. Klose
    • 1
  • B. P. Arulanandam
    • 1
    Email author
  1. 1.Department of Biology, South Texas Center for Emerging Infectious DiseasesUniversity of Texas at San AntonioSan AntonioUSA

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