The presence of infectious extracellular Francisella tularensis subsp. novicida in murine plasma after pulmonary challenge
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Francisella tularensis is a gram-negative, facultative intracellular bacterium and is the causative agent of the zoonotic disease tularemia . F. tularensis has been considered a potential biological weapon due to its low infectious dose and high mortality rate . F. tularensis can be classified into several subspecies, including those relevant to human disease: F. tularensis subsp. tularensis (type A) and F. tularensis subsp. holarctica (type B); F. novicida and F. mediasiatica . However, most of our knowledge about the pathogenesis of Francisella and the immune responses to the infection have come from studies of F. tularensis LVS (derived from holartica) and F. novicida [4, 5, 6]. Both organisms are attenuated in humans, while retaining virulence in mice. It is well established that Francisellaenters and replicates within host cells, and a strong research focus has been on deciphering the mechanisms for intramacrophage growth. However, little is known about the...
KeywordsIntracellular Bacterium Tularemia Francisella Tularensis Secondary Organ Tularensis Subsp
This work was supported by National Institutes of Health grant PO1 AI057986. The authors thank Michael Pammit from UTSA for technical expertise.