Molecular characterisation of invasive Streptococcus pyogenes isolates from Hungary obtained in 2004 and 2005

  • B. KrucsóEmail author
  • M. Gacs
  • B. Libisch
  • Zs. Vargáné Hunyadi
  • K. Molnár
  • M. Füzi
  • J. Pászti
Concise Article


Our aim was to characterise by molecular techniques group A streptococci isolated from invasive infections in Hungary in 2004–2005. Twenty-six nonduplicate invasive GAS isolates were selected and examined. The mortality rate proved high (52.3%) for those cases (n = 21) where data were available. Predominant emm types were emm1 (n = 13, 50%) and emm80 (n = 5, 19.2%), but other M types (emm4, emm28, emm66, emm81.1, emm82, emm84) were also identified. Eight different PFGE types were distinguished, and each emm type showed an individual PFGE pattern. Our results show that—similarly to results obtained in several other countries—emm type 1 strains predominate among invasive GAS isolates, and that emm 1 type strains recovered from severe streptococcal infections were associated with the presence of the speA gene. The rate for macrolide resistance proved low: only two isolates showed elevated MICs for erythromycin.


Necrotizing Fasciitis Toxic Shock Syndrome Scarlet Fever PFGE Pattern Streptococcal Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



group A streptococcus


toxic shock syndrome


pulsed-field gel electrophoresis


National Center for Epidemiology


Clinical and Laboratory Standards Institute


Centres for Disease Control and Prevention


intrauterine device


pyrrolidonyl arylamidase


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • B. Krucsó
    • 1
    Email author
  • M. Gacs
    • 2
  • B. Libisch
    • 2
  • Zs. Vargáné Hunyadi
    • 1
  • K. Molnár
    • 3
  • M. Füzi
    • 2
  • J. Pászti
    • 1
  1. 1.Department of Phage Typing and Molecular EpidemiologyNational Center for EpidemiologyBudapestHungary
  2. 2.Department of BacteriologyNational Center for EpidemiologyBudapestHungary
  3. 3.Office of the Chief Medical OfficerBudapestHungary

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