Coxiella burnetii infection of aortic aneurysms or vascular grafts: report of 30 new cases and evaluation of outcome

  • E. Botelho-Nevers
  • P.-E. Fournier
  • H. Richet
  • F. Fenollar
  • H. Lepidi
  • C. Foucault
  • A. Branchereau
  • P. Piquet
  • M. Maurin
  • D. Raoult
Article

Abstract

Q fever is a zoonotic disease caused by Coxiella burnetii. Polymorphic, the disease may present as an acute or chronic infection. Vascular infections are the second most common form of chronic Q fever, following endocarditis. Herein, we studied the outcome of 30 new cases of aortic infection caused by C. burnetii using uni- and multivariate analyses. The outcome of ten cases previously reported by our team was also updated. Of these 40 patients, 32 had a follow-up of ≥3 years. Among them, the overall mortality was of 25% (8/32). Vascular rupture was significantly and independently (multivariate P=0.03) associated with a lethal issue, whereas vascular surgery was significantly associated with recovery (uni- and multivariate P<0.01). Our findings demonstrate the critical importance of surgery in the management of C. burnetii vascular infections.

Notes

Acknowledgements

The authors are grateful to Drs. Alamartine, Becq-Giraudon, Besnier, Beytout, Bosseret, Bouchou, Cottin, Faux, Glichmanas, Hamidou, Heibel, Labrun, Martin, May, Millet, Perez, Raz, Tellez, and Vigier for providing clinical information, and Dr. Cutler for English revision.

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • E. Botelho-Nevers
    • 1
  • P.-E. Fournier
    • 1
  • H. Richet
    • 1
  • F. Fenollar
    • 1
  • H. Lepidi
    • 1
  • C. Foucault
    • 1
  • A. Branchereau
    • 2
  • P. Piquet
    • 3
  • M. Maurin
    • 4
  • D. Raoult
    • 1
  1. 1.Unité des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de MédecineUniversité de la MéditerranéeMarseille Cedex 5France
  2. 2.Service de Chirurgie VasculaireHôpital de la TimoneMarseilleFrance
  3. 3.Service de Chirurgie VasculaireHôpital Sainte-MargueriteMarseilleFrance
  4. 4.Laboratoire de BactériologieHôpital MichallonGrenobleFrance

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