Human herpesvirus 6 in the newborn intensive care unit

  • A. C. RentzEmail author
  • J. Stevenson
  • W. Hymas
  • D. Hillyard
  • G. J. Stoddard
  • E. W. Taggart
  • C. L. Byington
Brief Report

Human herpesvirus 6 (HHV-6) is a ubiquitous DNA virus that causes roseola and may cause life-threatening illness in immune compromised hosts. Peak acquisition of the virus occurs between 6 and 9 months of age, but earlier acquisition has been reported [1]. Congenital infection has been postulated, but the clinical significance is unclear [2, 3, 4, 5]. Chromosomal integration and subsequent detection of HHV-6 DNA has recently been demonstrated, contributing to the confounding effect of detecting the virus in neonates and defining congenitally acquired infection [6]. We hypothesize that congenital HHV-6 may occur and cause “sepsis-like” episodes in infants cared for in the neonatal intensive care unit (NICU).

A pilot cross-sectional study was performed to obtain an estimate of HHV-6 DNA prevalence in the NICU. All infants hospitalized in the Primary Children’s Medical Center (PCMC) NICU between December 2002 and November 2003 were eligible for inclusion. Investigators collected samples...


Neonatal Intensive Care Unit Congenital Infection Chromosomal Integration Cytel Jejunal Atresia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • A. C. Rentz
    • 1
    • 4
    Email author
  • J. Stevenson
    • 2
  • W. Hymas
    • 2
  • D. Hillyard
    • 2
  • G. J. Stoddard
    • 3
  • E. W. Taggart
    • 2
  • C. L. Byington
    • 1
  1. 1.Department of PediatricsUniversity of UtahSalt Lake CityUSA
  2. 2.Associated Regional University PathologistsSalt Lake CityUSA
  3. 3.Division of EpidemiologyUniversity of UtahSalt Lake CityUSA
  4. 4.Neonatology Associates, St. Vincent’s HealthcareBillingsUSA

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