Rat-bite fever septic arthritis: illustrative case and literature review

  • C. Dendle
  • I. J. Woolley
  • T. M. Korman


Rat-bite fever is a rare zoonotic infection caused by Streptobacillus moniliformis or Spirillum minus, which is characterised by fever, rash and arthritis. The arthritis has previously been described as non-suppurative and isolation of the organism from synovial fluid as very uncommon. This article reports a case of septic arthritis diagnosed as rat-bite fever when the organism was cultured from synovial fluid and reviews another 15 cases of S. moniliformis septic arthritis reported in the worldwide literature since 1985. Articles were included in this review if S. moniliformis was cultured from synovial fluid. Of the published cases, 88% presented with polyarthritis, affecting small and large joints although two had monoarticular hip sepsis. Fever was present in 88%, rash in 25% and 56% had extra-articular features. Synovial fluid analysis revealed high cell counts in all cases (mean 51,000 × 109/l) with a predominance of polymorphonuclear leucocytes, and organisms were found on Gram stain in only 50%. Penicillin was used for treatment in 56% of cases and surgery was required in 30%. All patients recovered. Rat-bite fever arthritis can be suppurative and attempts should be made to isolate the organism from synovial fluid. The diagnosis should be considered when there is arthritis and a high synovial fluid cell count but no apparent organism, especially when the patient has had contact with rats.


Synovial Fluid Infective Endocarditis Septic Arthritis Leucocyte Count Leptospirosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Jenny Davis and Margaret Whipp at the Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne are acknowledged for identification of the isolate, for the photograph in Fig. 1 (JD) and for 16S rRNA gene sequencing (MW).

Kristine Roney at Dorevich Pathology, Frankston, is acknowledged for initial culture and characterisation of the isolate. Dr. J. Honig at Eramosa Family Medical Centre, Somerville is acknowledged for providing clinical details.


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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  1. 1.Department of Infectious DiseasesMonash Medical CentreClaytonAustralia
  2. 2.Department of MedicineMonash UniversityClaytonAustralia

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