Staphylococcus aureus positive for Panton-Valentine leukocidin genes but susceptible to methicillin in patients with furuncles
- 88 Downloads
A total of 75 Staphylococcus aureus isolates obtained from patients with either recurrent skin abscesses or furuncles (n=48) or chronic infections from other body sites (n=27) were screened for the presence of the lukS-PV and lukF-PV genes encoding Panton-Valentine leukocidin. Significantly more isolates (70.8% vs. 7.4%, p<0.001) from patients suffering skin abscesses or furuncles were positive for lukS-PV and lukF-PV. These isolates belonged to the accessory gene regulator (agr) group Ia (9/48), group III (13/48), or group IV (19/48). In contrast with results of other investigations, none of the isolates positive for the Panton-Valentine leukocidin genes in this study exhibited methicillin resistance.
KeywordsStaphylococcus Aureus Methicillin Resistance Exfoliative Toxin Skin Abscess Accessory Gene Regulator
ON is supported by grant 13N8348 (BMBF, Germany)
- 5.EURO-ATVo:CARD- Consortium (2002) Autovaccination and therapeutic vaccination to combat antibiotic resistance development. http://www.euro-atvocard.de. Cited 21 Jan 2005
- 8.Becker K, Roth R, Peters G (1998) Rapid and specific detection of toxigenic Staphylococcus aureus: use of two multiplex PCR enzyme immunoassays for amplification and hybridization of staphylococcal enterotoxin genes, exfoliative toxin genes, and toxic shock toxin 1 gene. J Clin Microbiol 36:2548–2553Google Scholar
- 10.Projan SJ, Novick RP (1997) The molecular basis of pathogenicity. In: Crossley KB, Archer GL (eds) The staphylococci in human disease. Churchill Livingston, New York, Edingburgh, London, Madrid, Melbourne, San Francisco, Tokyo, pp 55–82Google Scholar