VIM-2 metallo-β-lactamase in Achromobacter xylosoxidans in Europe
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During the last decade, acquired metallo-β-lactamases (MBLs) have started to emerge among Pseudomonas aeruginosa isolates and other gram-negative nosocomial pathogens. The enzymes readily hydrolyse all β-lactam agents except monobactams and are encoded by genes carried in class 1 integrons . Two major groups of acquired MBLs, the IMP and VIM enzymes, have been identified in gram-negative species; more than 15 different IMP allelic variants have been detected, while the 11 VIM allelic variants that have been identified up to now are divided into the three major amino acid sequence subgroups VIM-1, VIM-2 and VIM-7 (http:\www.lahey.org\studies\other.asp). blaIMP genes have been described mainly in Japan but also in other Asian countries and some European and American regions, while blaVIM genes have been detected mostly in Mediterranean countries of Europe and several Far East regions .
Achromobacter xylosoxidans (synonym: Alcaligenes xylosoxidans) is an opportunistic gram-negative...
KeywordsImipenem Colistin Netilmicin Conjugational Transfer Pleural Empyema
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