Double hepatitis B virus infection in a patient with HIV/hepatitis C virus coinfection and ‘anti-HBc alone’ as serological pattern
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- Wagner, A.A., Loustaud-Ratti, V., Chemin, I. et al. Eur J Clin Microbiol Infect Dis (2005) 24: 623. doi:10.1007/s10096-005-0010-1
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Reported here is a case of double hepatitis B virus (HBV) infection in an HIV/hepatitis C virus (HCV)-coinfected patient with antibodies against hepatitis B core antigen as the only serological marker (anti-HBc alone). Two different HBV genotypes were identified in this patient. A search of the medical literature indicated this report is the first to describe a multiple silent HBV infection in an HIV/HCV-coinfected-patient. The elevated incidence of the anti-HBc alone pattern in HIV-positive patients and the increasing number of silent HBV infections detected in those patients demonstrate the need to carefully examine HIV-positive patients for occult HBV infection. In addition, it appears necessary to thoroughly study such patients in order to evaluate the impact of mixed HBV infection and triple HIV/HCV/HBV infection on morbidity.