Double hepatitis B virus infection in a patient with HIV/hepatitis C virus coinfection and ‘anti-HBc alone’ as serological pattern

  • A. A. Wagner
  • V. Loustaud-Ratti
  • I. Chemin
  • P. Weinbreck
  • F. Denis
  • S. Alain
Concise Article

DOI: 10.1007/s10096-005-0010-1

Cite this article as:
Wagner, A.A., Loustaud-Ratti, V., Chemin, I. et al. Eur J Clin Microbiol Infect Dis (2005) 24: 623. doi:10.1007/s10096-005-0010-1

Abstract

Reported here is a case of double hepatitis B virus (HBV) infection in an HIV/hepatitis C virus (HCV)-coinfected patient with antibodies against hepatitis B core antigen as the only serological marker (anti-HBc alone). Two different HBV genotypes were identified in this patient. A search of the medical literature indicated this report is the first to describe a multiple silent HBV infection in an HIV/HCV-coinfected-patient. The elevated incidence of the anti-HBc alone pattern in HIV-positive patients and the increasing number of silent HBV infections detected in those patients demonstrate the need to carefully examine HIV-positive patients for occult HBV infection. In addition, it appears necessary to thoroughly study such patients in order to evaluate the impact of mixed HBV infection and triple HIV/HCV/HBV infection on morbidity.

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • A. A. Wagner
    • 1
  • V. Loustaud-Ratti
    • 2
  • I. Chemin
    • 3
  • P. Weinbreck
    • 4
  • F. Denis
    • 1
  • S. Alain
    • 1
  1. 1.Department of Bacteriology–Virology–HygieneTeaching Hospital CHU DupuytrenLimoges CedexFrance
  2. 2.Department of Internal MedicineTeaching Hospital CHU DupuytrenLimoges CedexFrance
  3. 3.U271 INSERMLyon Cedex 03France
  4. 4.Department of Infectious DiseasesTeaching Hospital CHU DupuytrenLimoges CedexFrance

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