Advertisement

Genotyping of urinary and fecal Proteus mirabilis isolates from individuals with long-term urinary catheters

  • S. MathurEmail author
  • N. A. Sabbuba
  • M. T. E. Suller
  • D. J. Stickler
  • R. C. L. Feneley
Brief Report

Bacterial colonization of the urinary tract is probably inevitable in those individuals undergoing long-term urinary catheterization. In approximately half of cases this leads to the complication of catheter encrustation, whereby the drainage lumen of the catheter is recurrently obstructed by crystalline biofilm, causing painful retention of urine or incontinence [1]. This is usually caused by organisms possessing the enzyme urease, particularly Proteus mirabilis [2]. Colonization usually occurs by the ascending route via the catheter, either through the internal drainage lumen as a result of contamination of the drainage apparatus, or along the external catheter surface by bacteria from the urethral meatus [3]. The external route is thought to be more important since closed drainage systems have become standard, and one phenotyping study of bacteriuria in subjects with short-term catheterization suggested an endogenous gastrointestinal origin for several common species [4]. In...

Keywords

Colistin Bacteriuria Proteus Mirabilis Urethral Meatus Suprapubic Catheter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

S.M. was supported by EPSRC grant GR/R66517/01.

References

  1. 1.
    Kohler-Ockmore J, Feneley RC (1996) Long-term catheterization of the bladder: prevalence and morbidity. Br J Urol 77:347–351PubMedGoogle Scholar
  2. 2.
    Mobley HL, Belas R (1995) Swarming and pathogenicity of Proteus mirabilis in the urinary tract. Trends Microbiol 3:280–284CrossRefPubMedGoogle Scholar
  3. 3.
    Nickel JC, Downey J, Costerton JW (1992) Movement of Pseudomonas aeruginosa along catheter surfaces. A mechanism in pathogenesis of catheter-associated infection. Urology 39:93–98CrossRefPubMedGoogle Scholar
  4. 4.
    Daifuku R, Stamm WE (1984) Association of rectal and urethral colonization with urinary tract infection in patients with indwelling catheters. JAMA 252:2028–2030CrossRefPubMedGoogle Scholar
  5. 5.
    Sabbuba NA, Mahenthiralingam E, Stickler DJ (2003) Molecular epidemiology of Proteus mirabilis infections of the catheterized urinary tract. J Clin Microbiol 41:4961–4965CrossRefPubMedGoogle Scholar
  6. 6.
    Clayton CL, Chawla JC, Stickler DJ (1982) Some observations on urinary tract infections in patients undergoing long-term bladder catheterization. J Hosp Infect 3:39–47CrossRefPubMedGoogle Scholar
  7. 7.
    Sabbuba NA, Stickler DJ, Mahenthiralingam E, Painter DJ, Parkin J, Feneley RC (2004) Genotyping demonstrates that the strains of Proteus mirabilis from bladder stones and catheter encrustations of patients undergoing long-term bladder catheterization are identical. J Urol 171:1925–1928CrossRefPubMedGoogle Scholar
  8. 8.
    Stickler DJ, Chawla JC (1987) The role of antiseptics in the management of patients with long-term indwelling bladder catheters. J Hosp Infect 10:219–228CrossRefPubMedGoogle Scholar
  9. 9.
    Muller HE (1986) Occurrence and pathogenic role of Morganella–Proteus–Providencia group bacteria in human feces. J Clin Microbiol 23:404–405PubMedGoogle Scholar
  10. 10.
    Peerbooms PG, Verweij AM, MacLaren DM (1985) Uropathogenic properties of Proteus mirabilis and Proteus vulgaris. J Med Microbiol 19:55–60PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • S. Mathur
    • 1
    Email author
  • N. A. Sabbuba
    • 2
  • M. T. E. Suller
    • 3
  • D. J. Stickler
    • 2
  • R. C. L. Feneley
    • 1
  1. 1.Bristol Urological InstituteSouthmead HospitalBristolUK
  2. 2.Cardiff School of BiosciencesCardiff UniversityCardiffUK
  3. 3.Faculty of Applied SciencesUniversity of the West of EnglandBristolUK

Personalised recommendations