Genotyping of urinary and fecal Proteus mirabilis isolates from individuals with long-term urinary catheters
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Bacterial colonization of the urinary tract is probably inevitable in those individuals undergoing long-term urinary catheterization. In approximately half of cases this leads to the complication of catheter encrustation, whereby the drainage lumen of the catheter is recurrently obstructed by crystalline biofilm, causing painful retention of urine or incontinence . This is usually caused by organisms possessing the enzyme urease, particularly Proteus mirabilis . Colonization usually occurs by the ascending route via the catheter, either through the internal drainage lumen as a result of contamination of the drainage apparatus, or along the external catheter surface by bacteria from the urethral meatus . The external route is thought to be more important since closed drainage systems have become standard, and one phenotyping study of bacteriuria in subjects with short-term catheterization suggested an endogenous gastrointestinal origin for several common species . In...
KeywordsColistin Bacteriuria Proteus Mirabilis Urethral Meatus Suprapubic Catheter
S.M. was supported by EPSRC grant GR/R66517/01.
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