Seoul hantavirus in Europe: first demonstration of the virus genome in wild Rattus norvegicus captured in France
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Although rats (Rattus rattus or Rattus norvegicus) worldwide have been found to carry Seoul hantavirus, there are at present only a very few reports of confirmed human Seoul hantavirus infections outside Asia, where the virus, in certain areas, is responsible for approximately 25% of the human hantavirus infections. In Europe, no confirmed human infections outside laboratories have been described, and although rats occasionally have been found to be antibody positive, the viral genome has not been demonstrated in these animals. The present report describes the first confirmed finding of Seoul hantavirus in R. norvegicus captured in Europe.
KeywordsGenetic Lineage Hemorrhagic Fever With Renal Syndrome Lung Tissue Sample Hantavirus Infection Nephropathia Epidemica
This study was made possible by grants STE/R and T WB11 from the Belgian Ministry of Defence, and grants RFA915 and 202012 from the Academy of Finland. The collection of rats was carried out during a preliminary research program on PUUV infection in bank voles (AER 2002), a program supported by the Veterinary School of Lyon in collaboration with Claude Bernard University, Lyon, and the Pasteur Institute, Paris. The experiments described comply with current European Union laws and regulations.
- 1.Elliott RM, Bouloy M, Calisher CH, Goldbach R, Moyer JT, Nichol ST, Pettersson R, Plyusnin A, Schmaljohn CS (2000) Bunyaviridae. In: van Regenmortel MHV, Fauquet CM, Bishop DHL, Carsten EB, Estes MK, Lemon SM, Maniloff J, Mayo MA, McGeoch DJ, Pringle CR, Wickner RB (eds) Virus taxonomy. VII report of the international committee on taxonomy of viruses. Academic, San Diego, pp 599–621Google Scholar
- 3.Brummer-Korvenkontio M, Henttonen H, Vaheri A (1982) Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica. Scand J Infect Dis 36(Suppl):88–91Google Scholar
- 6.Nemirov K, Vapalahti O, Lundkvist A, Vasilenko V, Golovljova I, Plyusnina A, Niemimaa J, Laakkonen J, Henttonen H, Vaheri A, Plyusnin A (1999) Isolation and characterization of Dobrava hantavirus carried by the striped field mouse (Apodemus agrarius) in Estonia. J Gen Virol 80(Pt 2):371–379PubMedGoogle Scholar
- 8.Plyusnin A, Vapalahti O, Lankinen H, Lehvaslaiho H, Apekina N, Myasnikov Y, Kallio-Kokko H, Henttonen H, Lundkvist A, Brummer-Korvenkontio M (1994) Tula virus: a newly detected hantavirus carried by European common voles. J Virol 68:7833–7839Google Scholar
- 12.Klempa B, Meisel H, Rath S, Bartel J, Ulrich R, Kruger DH (2003) Occurrence of renal and pulmonary syndrome in a region of northeast Germany where Tula hantavirus circulates. J Clin Microbiol 41:4894–4897Google Scholar
- 13.Schultze D, Lundkvist A, Blauenstein U, Heyman P (2002) Tula virus infection associated with fever and exanthema after a wild rodent bite. Eur J Clin Microbiol Infect Dis 21:304–306Google Scholar
- 21.Glass GE, Watson AJ, Leduc JW, Childs JE (1994) Domestic cases of hemorrhagic fever with renal syndrome in the United States. Nephron 68:48–51Google Scholar
- 24.Kariwa H, Kimura M, Yoshizumi S, Arikawa J, Yoshimatsu K, Takashima I, Hashimoto N (1996) Modes of Seoul virus infections: persistency in newborn rats and transiency in adult rats. Arch Virol 141:2327–2338Google Scholar
- 25.Lee HW (1996) Epidemiology and pathogenesis of hemorrhagic fever with renal syndrome. In: Elliott RM (ed) The Bunyaviridae. Plenum, New York, pp 253–267Google Scholar
- 27.Mitchell-Jones AJ, Amori G, Bogdanowicz W, Krystufek B, Reijnders PJH, Spitzenberger F, Stubbe M, Thissen JBM, Vohralik V, Zima J (1999) The atlas of European mammals. Academic, San Diego, pp 278Google Scholar
- 28.Krinke GJ (2000) The laboratory rat. Academic Press, San DiegoGoogle Scholar