Mycobacterium malmoense lymphadenitis in Spain: first two cases in immunocompetent patients

  • A. I. López-Calleja
  • M. A. Lezcano
  • S. Samper
  • F. de Juan
  • M. J. Revillo
Concise Article

Abstract

Reported here are two cases of Mycobacterium malmoense lymphadenitis that occurred in two immunocompetent children in Spain. To the best of our knowledge, these are the first documented cases of extrapulmonary infection by M. malmoense in Spain. This report serves to draw attention to this emerging nontuberculous mycobacterium that is gaining increasing recognition as a pulmonary and extrapulmonary pathogen in different countries.

References

  1. 1.
    Schröder KH, Juhlin I (1977) Mycobacterium malmoense sp. nov. Int J Syst Bacteriol 27:241–246Google Scholar
  2. 2.
    Henriques B, Hoffner SE, Petrini B, Juhlin I, Walhen P, Kallenius G (1994) Infection with Mycobacterium malmoense in Sweden: report of 221 cases. Clin Infect Dis 18:596–600PubMedGoogle Scholar
  3. 3.
    Lamden K, Watson JM, Knerer G, Ryan MJ, Jenkins PA (1996) Opportunist mycobacteria in England and Wales: 1982 to 1994. Commun Dis Rep CDR Rev 6:R147–R151PubMedGoogle Scholar
  4. 4.
    Tortoli E, Piersimoni C, Bartolini A, Burrini C, Callegaro AP, Caroli G et al (1997) Mycobacterium malmoense in Italy: the modern Norman invasion? Eur J Epidemiol 13:341–346CrossRefPubMedGoogle Scholar
  5. 5.
    Buchholz UT, McNeil MM, Keyes LE, Good RC (1998) Mycobacterium malmoense infections in the United States, January 1993 through June 1995. Clin Infect Dis 27:551–558PubMedGoogle Scholar
  6. 6.
    Zaugg M, Salfinger M, Opravil M, Lüthy R (1993) Extrapulmonary and disseminated infections due to Mycobacterium malmoense: case report and review. Clin Infect Dis 16:540–549PubMedGoogle Scholar
  7. 7.
    Telenti A, Marchesi F, Balz M, Bally F, Böttger EC, Bodmer T (1993) Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis. J Clin Microbiol 31:175–178PubMedGoogle Scholar
  8. 8.
    Kirschner P, Springer B, Vogel U, Meier A, Wrede A, Kiekenbeck M et al (1993) Genotypic identification of mycobacteria by nucleic acid sequence determination: report of a 2-year experience in a clinical laboratory. J Clin Microbiol 31:2882–2889PubMedGoogle Scholar
  9. 9.
    Chocarro A, González-López A, Breznes MF, Canut A, Rodríguez J, Diego JM (1994) Disseminated infection due to Mycobacterium malmoense in a patient infected with human immunodeficiency virus. Clin Infect Dis 19:203–204PubMedGoogle Scholar
  10. 10.
    López R, Redondo MP, Ruiz D, Geijo P (1997) Infección pulmonar por Mycobacterium malmoense en un paciente con SIDA. Enferm Infecc Microbiol Clin 15:47–48Google Scholar
  11. 11.
    Ruiz M, Rodríguez JC, García-Martinez J, Escribano I, Sirvent E, Gutiérrez F, et al (2002) Molecular characterization of a Spanish isolate of Mycobacterium malmoense. Res Microbiol 153:33–36CrossRefPubMedGoogle Scholar
  12. 12.
    Alberte A, Pascual PP, Represa CL, Manrique A (1995) Pulmonary pathology and an infrequent Mycobacterium malmoense in Spain. An Med Interna 12:203–204PubMedGoogle Scholar
  13. 13.
    Starke JF, Correa AG (1995) Management of mycobacterial infection and disease in children. Pediatr Infect Dis J 14:455–470PubMedGoogle Scholar
  14. 14.
    Enzensberger R, Hunfeld KP, Krause M, Rüsch-Gerdes S, Brade V, Böddinghaus B (1999) Mycobacterium malmoense infections in immunocompetent patients. Eur J Clin Microbiol Infect Dis 18:579–581CrossRefPubMedGoogle Scholar
  15. 15.
    Hoffner SE, Henriques B, Petrini B, Kallenius G (1991) Mycobacterium malmoense: an easily missed pathogen. J Clin Microbiol 29:2673–2674PubMedGoogle Scholar
  16. 16.
    Pfyffer GE, Brown-Elliot BA, Wallace RJ Jr (2003) Mycobacterium: general characteristics, isolation, and staining procedures. In: Murray PR, Baron EJ, Jorgensen JH, Pfaller MA, Yolken RH (eds) Manual of clinical microbiology. American Society for Microbiology, Washington DC, p 549Google Scholar
  17. 17.
    Burucoa C, Bourgoin A, Castets M, Dor P, Recart D, Vincent V (1993) Pulmonary infection due to Mycobacterium malmoense in an immunocompromised patient. Clin Microbiol Newslett 15:86–87CrossRefGoogle Scholar
  18. 18.
    Al-Moamary MA, Black W, Elwood K (1998) Pulmonary disease to Mycobacterium malmoense in British Columbia. Can Respir J 5:135–138PubMedGoogle Scholar
  19. 19.
    Portaels F, Larsson L, Jenkins PA (1995) Isolation of Mycobacterium malmoense from the environment in Zaire. Tuber Lung Dis 76:160–162PubMedGoogle Scholar
  20. 20.
    Doig C, Muckersie L, Watt B, Forbes KJ (2002) Molecular epidemiology of Mycobacterium malmoense infections in Scotland. J Clin Microbiol 40:1103–1105CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • A. I. López-Calleja
    • 1
  • M. A. Lezcano
    • 1
    • 2
  • S. Samper
    • 1
    • 2
  • F. de Juan
    • 3
  • M. J. Revillo
    • 1
  1. 1.Department of MicrobiologyMiguel Servet University HospitalZaragozaSpain
  2. 2.Mycobacteria Genetic GroupUniversity of ZaragozaZaragozaSpain
  3. 3.Department of Paediatric Infectious DiseasesMiguel Servet University HospitalZaragozaSpain

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