Cerebrospinal Fluid Penetration and Pharmacokinetic/Pharmacodynamic Parameters of Intravenously Administered Colistin in a Case of Multidrug-Resistant Acinetobacter baumannii Meningitis

  • M. Jiménez-Mejías
  • C. Pichardo-Guerrero
  • F. Márquez-Rivas
  • D. Martín-Lozano
  • T. Prados
  • J. Pachón
Concise Article

Abstract

Described here is a case of meningitis caused by multidrug-resistant Acinetobacter baumannii susceptible only to colistin, which was treated successfully with intravenous colistin sulfomethate sodium (5 mg/kg/day). The levels of colistin in serum and cerebrospinal fluid and the pharmacokinetic/pharmacodynamic parameters of colistin were determined. In this case, intravenously administered colistin penetrated cerebrospinal fluid (25% of serum levels) at levels sustaining bactericidal concentrations.

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • M. Jiménez-Mejías
    • 1
  • C. Pichardo-Guerrero
    • 1
  • F. Márquez-Rivas
    • 2
  • D. Martín-Lozano
    • 1
  • T. Prados
    • 3
  • J. Pachón
    • 1
  1. 1.Service of Infectious Diseases, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 SevilleSpain
  2. 2.Service of Neurosurgery, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 SevilleSpain
  3. 3.Service of Microbiology, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 SevilleSpain

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