Screening antiacne potency of Indonesian medicinal plants: antibacterial, lipase inhibition, and antioxidant activities
Indonesian medicinal plants were screened as potential sources of antiacne agents. The screening methods were performed using antibacterial assay against Propionibacterium acnes, lipase inhibitor assay, and antioxidant assay. The results showed that from 40 plant materials extracted with methanol and 50% ethanol in water, Caesalpinia sappan was the best extract based on the combined activities: antibacterial (minimum inhibitory concentration 0.13 mg/ml; minimum bactericidal concentration 0.25 mg/ml), lipase inhibitory [50% inhibitory concentration (IC50) 120.0 μg/ml], and antioxidative (IC50 6.47 μg/ml). Another prospective extract is Intsia palembanica based on its lipase inhibitory activity (IC50 4.1 μg/ml) and antioxidant activity (IC50 3.87 μg/ml).
Key wordsIndonesian medicinal plants Propionibacterium acnes Lipase inhibitor Antioxidant
Unable to display preview. Download preview PDF.
- 13.Furukawa I, Kurooka S, Arisue K, Kohda K, Hayashi C (1982) Assays of serum lipase by the “BALB-DTNB Method” mechanized for use with discrete and continuous-flow analyzer. Clin Chem 26:110–113Google Scholar
- 14.Sangat HM, Zuhud EAM, Damayanti EK (2000) Kamus Penyakit dan Tumbuhan Obat Indonesia [Etnofi tomedika I] (in Indonesian). Yayasan Obor, IndonesiaGoogle Scholar
- 17.Ng LT, Yap SF (2003) Gynura Cass. In: Lemmens RHMJ, Bunyapraphatsara N (eds) Plant resources of South East Asia No 12 (3). Medicinal and poisonous plants 3. Prosea Foundation, Bogor, Indonesia, pp 231–233Google Scholar