Journal of Wood Science

, Volume 54, Issue 2, pp 179–181 | Cite as

Inhibitory effects of l-pipecolic acid from the edible mushroom, Sarcodon aspratus, on angiotensin I-converting enzyme

  • Masaaki Kiyoto
  • Shingo Saito
  • Kazuyuki Hattori
  • Nam-Seok Cho
  • Takaaki Hara
  • Yuzo Yagi
  • Masakazu Aoyama
Note

Abstract

The aqueous extract of the edible mushroom Sarcodon aspratus showed inhibitory effects against angiotensin I-converting enzyme (ACE). l-Pipecolic acid (l-piperidine-2-carboxylic acid) was isolated from a hot-water extract in a 0.02% yield as an active principle. The mode of inhibition of l-pipecolic acid was found to be competitive, whereas its d-isomer showed no significant inhibitory effects against ACE, suggesting that the configuration of the carboxyl group in the molecule plays an important role in the enzyme inhibition.

Key words

Angiotensin I-converting enzyme (ACE) Antihypertensive agent l-Pipecolic acid Sarcodon aspratus 

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Copyright information

© The Japan Wood Research Society 2007

Authors and Affiliations

  • Masaaki Kiyoto
    • 1
  • Shingo Saito
    • 2
  • Kazuyuki Hattori
    • 1
  • Nam-Seok Cho
    • 3
  • Takaaki Hara
    • 4
  • Yuzo Yagi
    • 4
  • Masakazu Aoyama
    • 1
  1. 1.Department of Applied and Environmental ChemistryKitami Institute of TechnologyKitamiJapan
  2. 2.Graduate School of Science and EngineeringSaitama UniversitySaitamaJapan
  3. 3.College of Agriculture, Life and Environmental ScienceChungbuk National UniversityCheongjuKorea
  4. 4.Hakuju Life Science Co., Ltd.TokyoJapan

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