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Neurological Sciences

, Volume 24, Supplement 2, pp s143–s145 | Cite as

Hypothalamic deep brain stimulation for intractable chronic cluster headache: a 3-year follow-up

  • M. Leone
  • A. Franzini
  • G. Broggi
  • G. Bussone
NEW PERSPECTIVES ON CHRONIC HEADACHES

Abstract.

Cluster headache is the most severe among primary headaches. Positron emission tomography and functional MRI studies have demonstrated that the ipsilateral posterior hypothalamus is activated during cluster headache attacks and is structurally asymmetric in these patients thus indicating that cluster headache may originate at that level. These hypothalamic abnormalities in cluster headache led to the suggestion that deep brain stimulation of ipsilateral posterior inferior hypothalamus might produce clinical improvement in otherwise treatment refractory chronic cluster headache patients. In a patient with severe intractable chronic cluster headache, hypothalamic electrical stimulation produced complete and long-term pain relief with no relevant side effects. So far other operations have been performed and the results are encouraging in terms of both pain relief and safety. The efficacy of hypothalamic electrical stimulation provides some hints into cluster headache pathophysiology.

Key words Cluster headache Hypothalamus Deep brain stimulation Therapy Pathophysiology 

Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • M. Leone
    • 1
  • A. Franzini
    • 2
  • G. Broggi
    • 2
  • G. Bussone
    • 1
  1. 1.Headache Centre, Cerebrovascular Disease Department, C. Besta National Neurological Institute, Via Celoria 11, I-20133 Milan, ItalyIT
  2. 2.Department of Neurosurgery, C. Besta National Neurological Institute, Milan, ItalyIT

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