Neurological Sciences

, Volume 22, Issue 1, pp 89–91

Reduced L-dopa absorption and increased clinical fluctuations in Helicobacter pylori-infected Parkinson's disease patients

  • M. Pierantozzi
  • A. Pietroiusti
  • G. Sancesario
  • G. Lunardi
  • E. Fedele
  • P. Giacomini
  • S. Frasca
  • A. Galante
  • M. G. Marciani
  • P. Stanzione

DOI: 10.1007/s100720170061

Cite this article as:
Pierantozzi, M., Pietroiusti, A., Sancesario, G. et al. Neurol Sci (2001) 22: 89. doi:10.1007/s100720170061

Abstract

We report that the area under the cure of L-dopa plasma concentration, following the administration of a single 250 mg L-dopa dose, is augmented after Helicobacter pylori (HP) eradication in six Parkinson's disease (PD) patients showing high IgG antibody titer against HP. A prolongation of L-dopa clinical benefit was also observed. We suggest that HP infection-activated gastric alterations may be responsible, at least in part, for the reported erratic efficacy or oral L-dopa therapy in some advanced PD patients. Given the high percentage of HP-positivity in the age cohorts including the largest prevalence of PD patients, we propose that HP eradication be recommended in all PD patients under L-dopa therapy.

Copyright information

© Springer-Verlag Italia 2001

Authors and Affiliations

  • M. Pierantozzi
    • 1
  • A. Pietroiusti
    • 3
  • G. Sancesario
    • 1
  • G. Lunardi
    • 4
  • E. Fedele
    • 5
  • P. Giacomini
    • 6
  • S. Frasca
    • 2
  • A. Galante
    • 3
  • M. G. Marciani
    • 1
  • P. Stanzione
    • 1
  1. 1.Neurological Clinic, University of Rome Tor Vergata, Rome, ItalyIT
  2. 2.IRCSS Fondazione S. Lucia, Via Ardeatina 306, I-00179 Rome, ItalyIT
  3. 3.Department of Internal Medicine, University of Rome Tor Vergata, Rome, ItalyIT
  4. 4.Laboratory of Pharmacology and Toxicology, Pharmacology and Neurosciences Service, IST, Genoa, ItalyIT
  5. 5.Department of Experimental Medicine, Section of Pharmacology and Toxicology, Genoa, ItalyIT
  6. 6.Nervous and Mental Disorders Clinic, University of Rome La Sapienza, Rome, ItalyIT
  7. 7.Department of Anesthesiology and Reanimation, University of Rome Tor Vergata, Rome, ItalyIT

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