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Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis

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Orthostatic hypotension (OH) is a common non-motor sign of Parkinson’s disease (PD). Several epidemiological studies have estimated the association between OH and PD with controversial results. Here, a meta-analysis was conducted to evaluate the association between them.


PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), VIP (Database of Chinese Scientific and Technical Periodicals), and Wanfang databases were searched for eligible publications from October 2003 to December 2017. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis. Random effect model was used to calculate the pooled odds ratio (OR) with 95% confidence intervals (CIs) from individual studies. Publication bias was estimated by Egger’s test, Begg’s test, and the funnel plot.


Nineteen studies involving 1620 PD patients and 898 healthy controls were included in this meta-analysis. The pooled estimate of the prevalence of OH in PD was 27.7% compared with 7.9% of that in control. The pooled OR of OH with PD was 4.343 (95% CI 3.323–5.676) with a low heterogeneity (I2 = 12.5%, Pheterogeneity = 0.301).


In the present meta-analysis, the pooled OR of OH with PD was 4.343 (95% CI 3.323–5.676) with a low heterogeneity, which showed a significant association between OH and increased risk of PD.

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Parkinson’s disease


Orthostatic hypotension


Odds ratio


Confidence intervals


Relative risks


Hazard ratios


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This work financially supported by the National Foundation of Natural Science of China (31771110, 31701020), Shandong Province Natural Science Foundation (ZR2019ZD31), the National Key Research and Development Program of China (2016YFC1306501), the Key Research and Development Program of Shandong Province (2018GSF118042), and Taishan Scholars Construction Project and Innovative Research Team of High-Level Local Universities in Shanghai.

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Correspondence to Hong Jiang.

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Mu, F., Jiao, Q., Du, X. et al. Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis. Neurol Sci (2020).

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  • Parkinson’s disease
  • Orthostatic hypotension
  • Meta-analysis
  • Odds ratio