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Hyperbaric oxygen therapy in acute stroke: is it time for Justitia to open her eyes?

  • Milija D. MijajlovicEmail author
  • Vuk Aleksic
  • Nenad Milosevic
  • Natan M. Bornstein
Review Article

Abstract

Hypoxia is a critical component of neuronal death in patients with stroke. Therefore increasing oxygenation of brain tissue seems to be a logical therapy against cerebral ischemia. Oxygen therapy exists in two modalities: normobaric hyperoxia therapy and hyperbaric oxygen therapy (HBO). HBO is a therapeutic procedure in which pure (100%) oxygen is administered at greater than atmospheric pressure in HBO therapy chambers. In this review article, we aimed to summarize the current knowledge regarding the therapeutic use of HBO in acute stroke patients. Literature review and electronic search were performed using PubMed, Medscape, and UpToDate with the keywords stroke, acute stroke, hyperbaric oxygen therapy, and hyperoxia. According to the reviewed literature, the use of HBO as routine stroke therapy cannot be justified in acute stage of stroke. More randomized, controlled studies are needed regarding safety and especially effectives of HBO in stroke patients. Also, standardized definition

of HBO should be proposed and used in all future studies.

Keywords

Stroke Hyperoxia Normobaric hyperoxia therapy Hyperbaric oxygen therapy 

Notes

Compliance with ethical standards

Conflict of interest

Authors have no potential conflicts of interest do disclose.

Ethical approval

Not applicable.

Research involving human participants and/or animals

Not applicable

Informed consent

Not applicable

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Copyright information

© Fondazione Società Italiana di Neurologia 2020

Authors and Affiliations

  1. 1.Neurology Clinic, Clinical Center of SerbiaFaculty of Medicine University of BelgradeBelgradeSerbia
  2. 2.Department of NeurosurgeryClinical Hospital Center ZemunBelgradeSerbia
  3. 3.Faculty of MedicineUniversity of Pristina - Kosovska MitrovicaKosovska MitrovicaSerbia
  4. 4.Department of Neurology, Tel-Aviv Sourasky Medical CenterTel-Aviv UniversityTel-AvivIsrael
  5. 5.ShaareZedek Medical CenterJerusalemIsrael

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